AZ-33
Based on 2 publication(s) in Google Scholar
AZ-33 (LDHA-IN-4) (compound 33) is a selective lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 0.5 μM and a Kd of 0.093 μM.
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- 純度: 98.14%
- CAS 番号: 1370290-34-8
- 分子式: C25H27N3O6S
- 分子量:497.56
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 AZ-33
More
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A673 | IC50 |
>20 μM
Compound: 1; 33
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Cytotoxicity against human A673 cells assessed as long term cell growth inhibition measured every 4 hrs for 120 hrs by incucyte zoom live cell analysis
Cytotoxicity against human A673 cells assessed as long term cell growth inhibition measured every 4 hrs for 120 hrs by incucyte zoom live cell analysis
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[PMID: 29120638] |
| A673 | IC50 |
>57 μM
Compound: 1; 33
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Cytotoxicity against human A673 cells after 48 hrs by CellTiter-Glo assay
Cytotoxicity against human A673 cells after 48 hrs by CellTiter-Glo assay
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[PMID: 29120638] |
| MIA PaCa-2 | IC50 |
>20 μM
Compound: 1; 33
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Cytotoxicity against human MIAPaCa2 cells assessed as long term cell growth inhibition measured every 4 hrs for 120 hrs by incucyte zoom live cell analysis
Cytotoxicity against human MIAPaCa2 cells assessed as long term cell growth inhibition measured every 4 hrs for 120 hrs by incucyte zoom live cell analysis
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[PMID: 29120638] |
| MIA PaCa-2 | IC50 |
>57 μM
Compound: 1; 33
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Cytotoxicity against human MIAPaCa2 cells after 48 hrs by CellTiter-Glo assay
Cytotoxicity against human MIAPaCa2 cells after 48 hrs by CellTiter-Glo assay
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[PMID: 29120638] |
HeLa cervical cancer cells were treated with 500 μM AZ-33 for 30 minutes. Liquid chromatography-mass spectrometry (LC-MS) analysis of the cell lysates revealed no residual AZ-33 within the cells, indicating poor cell permeability of AZ-33[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1370290-34-8
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性状 Solid
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分子量 497.56
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分子式 C25H27N3O6S
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Color White to off-white
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SMILES
O=C(C(CC1=CC=C(CCCC(NCCC(NC2=CC3=C(N=C(C)S3)C=C2)=O)=O)C=C1)C(O)=O)O
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別名
LDHA-IN-4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Rheumatoid arthritis synovial fibroblasts promote the glycolysis of myeloid-derived suppressor cells via TREM1/mTOR axis. [Abstract]2026 Sep 1:184:116961. PMID: 42242136 -
J Cell Mol Med
Identification of LDHA as a Potential Therapeutic Target for Pulmonary Hypertension Through Modulation of Endothelial-To-Mesenchymal Transition. [Abstract]2025 Jul;29(13):e70692. PMID: 40629253
溶剤 & 溶解度
DMSO : 100 mg/mL (200.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ward RA,et al. Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. J Med Chem. 2012 Apr 12;55(7):3285-306. [Content Brief]
[2]. Granchi C, et al. Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org Biomol Chem. 2013 Oct 14;11(38):6588-96. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0098 mL | 10.0490 mL | 20.0981 mL | 50.2452 mL |
| 5 mM | 0.4020 mL | 2.0098 mL | 4.0196 mL | 10.0490 mL | |
| 10 mM | 0.2010 mL | 1.0049 mL | 2.0098 mL | 5.0245 mL | |
| 15 mM | 0.1340 mL | 0.6699 mL | 1.3399 mL | 3.3497 mL | |
| 20 mM | 0.1005 mL | 0.5025 mL | 1.0049 mL | 2.5123 mL | |
| 25 mM | 0.0804 mL | 0.4020 mL | 0.8039 mL | 2.0098 mL | |
| 30 mM | 0.0670 mL | 0.3350 mL | 0.6699 mL | 1.6748 mL | |
| 40 mM | 0.0502 mL | 0.2512 mL | 0.5025 mL | 1.2561 mL | |
| 50 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0049 mL | |
| 60 mM | 0.0335 mL | 0.1675 mL | 0.3350 mL | 0.8374 mL | |
| 80 mM | 0.0251 mL | 0.1256 mL | 0.2512 mL | 0.6281 mL | |
| 100 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5025 mL |
AZ-33 関連分類
HY-18968 関連分類
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