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製品番号: HY-P11266

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Phakellistatin 13

Phakellistatin 13 is a natural cycloheptapeptide with anti-tumor activity. Phakellistatin 13 exhibits a potent inhibitory effect on liver cancer cells BEL-7404 (ED₅₀0 < 0.01 μg/mL). Phakellistatin 13 can be used for research on liver cancer.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 493012-52-5
分子式: C₄₂H₅₄N₈O₈
分子量:798.93

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Phakellistatin 13 構造式

CAS 番号: 493012-52-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	26.8 μM Compound: Phakellistatin 13	Antiproliferative activity against mouse 4T1 cells incubated for 48 hrs by MTT assay Antiproliferative activity against mouse 4T1 cells incubated for 48 hrs by MTT assay	[PMID: 38990190]
Bel-7402	ED₅₀	<0.01 μg/mL Compound: 3	Cytotoxicity against human Bel-7402 Cytotoxicity against human Bel-7402	[PMID: 17190452]
HeLa	IC₅₀	28.05 μM Compound: Phakellistatin 13	Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay	[PMID: 38990190]
HepG2	IC₅₀	13.1 μM Compound: Phakellistatin 13	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay	[PMID: 38990190]
L929	IC₅₀	>100 μM Compound: Phakellistatin 13	Antiproliferative activity against mouse L929 cells incubated for 48 hrs by MTT assay Antiproliferative activity against mouse L929 cells incubated for 48 hrs by MTT assay	[PMID: 38990190]
MDA-MB-231	IC₅₀	20.5 μM Compound: Phakellistatin 13	Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay	[PMID: 38990190]

化学情報

CAS 番号 493012-52-5
分子量 798.93
分子式 C₄₂H₅₄N₈O₈
配列

cyclo(Pro-Phe-Gly-Pro-Thr-Leu-Trp)
シーケンスの短縮

cyclo(PFGPTLW)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li T, et al. Exploring the Potential of Cyclic Peptidyl Antitumor Agents Derived from Natural Macrocyclic Peptide Phakellistatin 13. J Med Chem. 2024 Jul 25;67(14):11789-11813. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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