Pittsburgh Compound B
Based on 1 Customer Validation
Pittsburgh Compound B (PiB) is a blood-brain barrier-permeable, specific Aβ deposition PET tracer that binds to Aβ(1-40) fibrils with a Ki value of 678.4 nM. Through click chemical modification (a clickable Pittsburgh Compound B derivative is prepared by introducing a PEG3 linker and an alkynyl group at the 6-hydroxy site of Pittsburgh Compound B, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and enrichment and characterization of Aβ complexes. Pittsburgh Compound B is applicable to Alzheimer's disease research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 566169-93-5
- 分子式: C14H12N2OS
- 分子量:256.33
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Pittsburgh Compound B binds synthetic Aβ(1-40) fibrils with a Ki of 678.4 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 566169-93-5
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性状 Solid
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分子量 256.33
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分子式 C14H12N2OS
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Color Light yellow to yellow
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SMILES
OC1=CC=C2N=C(SC2=C1)C3=CC=C(C=C3)NC
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別名
PiB; 6-OH-BTA-1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : 50 mg/mL (195.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Diner I, et al. Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain. Bioconjug Chem. 2017;28(10):2627-2637. [Content Brief]
[2]. Rosen RF, et al. Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease. Acta Neuropathol. 2010;119(2):221-233. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9012 mL | 19.5061 mL | 39.0122 mL | 97.5305 mL |
| 5 mM | 0.7802 mL | 3.9012 mL | 7.8024 mL | 19.5061 mL | |
| 10 mM | 0.3901 mL | 1.9506 mL | 3.9012 mL | 9.7531 mL | |
| 15 mM | 0.2601 mL | 1.3004 mL | 2.6008 mL | 6.5020 mL | |
| 20 mM | 0.1951 mL | 0.9753 mL | 1.9506 mL | 4.8765 mL | |
| 25 mM | 0.1560 mL | 0.7802 mL | 1.5605 mL | 3.9012 mL | |
| 30 mM | 0.1300 mL | 0.6502 mL | 1.3004 mL | 3.2510 mL | |
| 40 mM | 0.0975 mL | 0.4877 mL | 0.9753 mL | 2.4383 mL | |
| 50 mM | 0.0780 mL | 0.3901 mL | 0.7802 mL | 1.9506 mL | |
| 60 mM | 0.0650 mL | 0.3251 mL | 0.6502 mL | 1.6255 mL | |
| 80 mM | 0.0488 mL | 0.2438 mL | 0.4877 mL | 1.2191 mL | |
| 100 mM | 0.0390 mL | 0.1951 mL | 0.3901 mL | 0.9753 mL |
Pittsburgh Compound B 関連分類
HY-126192 関連分類
Powered by Bioz
- Pittsburgh Compound B
- 566169-93-5
- PiB
- 6-OH-BTA-1
- Amyloid-β
- Ligands for Target Protein for PROTAC
- α-synuclein
- positron emission tomography (PET)
- β-amyloid (Aβ)
- temporal cortical homogenates
- aggregated amyloid beta (Aβ)
- blood-brain barrier
- Alzheimer's disease (AD)
- Aβ deposits
- Aβ(1-40) fibrils
- non-AD phenotype animal models
- occipital cortical homogenates
- Inhibitor
- inhibitor
- inhibit