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PolyQ aggregation inhibitor C2-8

(別名: Polyglutamine Aggregation inhibitor III)
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C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.

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  • 純度: 99.9%
  • CAS 番号: 300670-16-0
  • 分子式: C19H14Br2N2O3S
  • 分子量:510.20
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • PolyQ aggregation inhibitor C2-8 Chemical Structure
    PolyQ aggregation inhibitor C2-8 構造式
CAS 番号: 300670-16-0
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MOQ
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100 mg

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  • PolyQ aggregation inhibitor C2-8 Chemical Structure
    PolyQ aggregation inhibitor C2-8 Chemical Structure
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  • PolyQ aggregation inhibitor C2-8