300670-16-0
Chemical Structure
PolyQ aggregation inhibitor C2-8
Synonym(s): Polyglutamine Aggregation inhibitor III
- CAS No.: 300670-16-0
- Formula:C19H14Br2N2O3S
- Molecular Weight:510.20
IUPAC Name: N-(4-bromophenyl)-3-(N-(4-bromophenyl)sulfamoyl)benzamide
InChIKey: SJJKUNDBFWUAQB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(Br)C=C1)C2=CC=CC(S(=O)(NC3=CC=C(Br)C=C3)=O)=C2
Biological Activity: C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
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PolyQ aggregation inhibitor C2-8 | 99.9% | C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease. | ||||||||||||||||||||
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Keywords
