The soft underbelly of tumor cells

  • Cell Res. 2014 Aug;24(8):910-1. doi: 10.1038/cr.2014.72.
Yufeng Shi  1 ,  S Kyun Lim  1 ,  Luis F Parada  1
Affiliations
  • 1. Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
PMID: 24874955 DOI: 10.1038/cr.2014.72
Abstract

In a recent Cell paper, Kitambi and colleagues identify a small molecule (Vacquinol-1) that has beneficial effects on a glioblastoma multiforme mouse model by oral administration. In glioblastoma cells, Vacquinol-1 targets macropinocytosis, a cellular process that will not lead to cell death in normal cells.

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