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  4. Vacquinol-1 dihydrochloride

Vacquinol-1 dihydrochloride  (Synonyms: NSC13316 dihydrochloride)

Cat. No.: HY-19345A Purity: 99.44%
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Vacquinol-1 (NSC13316) dihydrochloride is a MKK4-specific activator that activates MAPK pathways. Vacquinol-1 dihydrochloride specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model. Vacquinol-1 dihydrochloride also induces apoptosis in hepatocellular carcinoma (HCC)cell.

For research use only. We do not sell to patients.

Vacquinol-1 dihydrochloride Chemical Structure

Vacquinol-1 dihydrochloride Chemical Structure

CAS No. : 2309312-85-2

Size Price Stock Quantity
5 mg USD 130 In-stock
10 mg USD 220 In-stock
25 mg USD 460 In-stock
50 mg USD 780 In-stock
100 mg USD 1300 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Vacquinol-1 dihydrochloride:

Vacquinol-1 dihydrochloride Related Antibodies

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Description

Vacquinol-1 (NSC13316) dihydrochloride is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 dihydrochloride specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 dihydrochloride also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].

Molecular Weight

425.78

Formula

C21H23Cl3N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1NCCCC1)C2=CC(C3=CC=C(Cl)C=C3)=NC4=CC=CC=C24.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (58.72 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3486 mL 11.7432 mL 23.4863 mL
5 mM 0.4697 mL 2.3486 mL 4.6973 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 10 mg/mL (23.49 mM); Clear solution; Need ultrasonic and warming and heat to 44°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3486 mL 11.7432 mL 23.4863 mL 58.7158 mL
5 mM 0.4697 mL 2.3486 mL 4.6973 mL 11.7432 mL
10 mM 0.2349 mL 1.1743 mL 2.3486 mL 5.8716 mL
15 mM 0.1566 mL 0.7829 mL 1.5658 mL 3.9144 mL
20 mM 0.1174 mL 0.5872 mL 1.1743 mL 2.9358 mL
25 mM 0.0939 mL 0.4697 mL 0.9395 mL 2.3486 mL
30 mM 0.0783 mL 0.3914 mL 0.7829 mL 1.9572 mL
40 mM 0.0587 mL 0.2936 mL 0.5872 mL 1.4679 mL
50 mM 0.0470 mL 0.2349 mL 0.4697 mL 1.1743 mL
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Vacquinol-1 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vacquinol-12309312-85-2NSC13316Vacquinol1Vacquinol 1NSC 13316NSC-13316OthersMKK4-specific activatoractivates MAPK pathwaysglioblastomaglioblastoma multiformeinduces apoptosishepatocellular carcinomaHCCInhibitorinhibitorinhibit

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