2309312-85-2
Chemical Structure
Vacquinol-1 dihydrochloride
Synonym(s): NSC13316 dihydrochloride
- CAS No.: 2309312-85-2
- Formula:C21H23Cl3N2O
- Molecular Weight:425.78
IUPAC Name: (2-(4-chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride
InChIKey: JSUQSKIIFVRRHP-UHFFFAOYSA-N
SMILES: OC(C1NCCCC1)C2=CC(C3=CC=C(Cl)C=C3)=NC4=CC=CC=C24.[H]Cl.[H]Cl
Biological Activity: Vacquinol-1 (NSC13316) dihydrochloride is a MKK4-specific activator that activates the MAPK pathway. Vacquinol-1 dihydrochloride inhibits the growth, migration and colony formation, and induces apoptosis of cancer cells. Vacquinol-1 dihydrochloride is applicable to research related to cancers such as hepatocellular carcinoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Vacquinol-1 dihydrochloride | 99.70% | Vacquinol-1 (NSC13316) dihydrochloride is a MKK4-specific activator that activates the MAPK pathway. Vacquinol-1 dihydrochloride inhibits the growth, migration and colony formation, and induces apoptosis of cancer cells. Vacquinol-1 dihydrochloride is applicable to research related to cancers such as hepatocellular carcinoma. | ||||||||||||||||||||
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- [1]. Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563. [Content Brief]
- [2]. Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137. [Content Brief]
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