2. Vacquinol-1

Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Vacquinol-1 dihydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Vacquinol-1 Chemical Structure

Vacquinol-1 Chemical Structure

CAS No. : 5428-80-8

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Vacquinol-1 Related Antibodies

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Description

Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].

Molecular Weight

352.86

Formula

C21H21ClN2O
CAS No.
SMILES

OC(C1NCCCC1)C2=CC(C3=CC=C(Cl)C=C3)=NC4=CC=CC=C24
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (85.02 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8340 mL 14.1699 mL 28.3399 mL
5 mM 0.5668 mL 2.8340 mL 5.6680 mL
View the Complete Stock Solution Preparation Table

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8340 mL 14.1699 mL 28.3399 mL 70.8496 mL
5 mM 0.5668 mL 2.8340 mL 5.6680 mL 14.1699 mL
10 mM 0.2834 mL 1.4170 mL 2.8340 mL 7.0850 mL
15 mM 0.1889 mL 0.9447 mL 1.8893 mL 4.7233 mL
20 mM 0.1417 mL 0.7085 mL 1.4170 mL 3.5425 mL
25 mM 0.1134 mL 0.5668 mL 1.1336 mL 2.8340 mL
30 mM 0.0945 mL 0.4723 mL 0.9447 mL 2.3617 mL
40 mM 0.0708 mL 0.3542 mL 0.7085 mL 1.7712 mL
50 mM 0.0567 mL 0.2834 mL 0.5668 mL 1.4170 mL
60 mM 0.0472 mL 0.2362 mL 0.4723 mL 1.1808 mL
80 mM 0.0354 mL 0.1771 mL 0.3542 mL 0.8856 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vacquinol-15428-80-8NSC13316Vacquinol1Vacquinol 1NSC 13316NSC-13316Inhibitorinhibitorinhibit

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