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RNF5-IN-1

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RNF5-IN-1 (FX12) is a selective RNF5 degrader. RNF5-IN-1 binds to RNF5 and inhibits its E3 activity, and promotes proteasomal degradation of RNF5 in an endoplasmic reticulum (ER)-associated degradation (ERAD) way in cells. RNF5-IN-1 inhibits α-1-antitrypsin (NHK) dislocation with an IC50 value of 2.7 μM. RNF5-IN-1 can be used for research of cystic fibrosis, acute myeloid leukemia, and certain viral infections.

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  • 純度: 98.52%
  • CAS 番号: 1807639-36-6
  • 分子式: C10H8O4S
  • 分子量:224.23
  • 保管条件:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • RNF5-IN-1 Chemical Structure
    RNF5-IN-1 構造式
CAS 番号: 1807639-36-6
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  • RNF5-IN-1 Chemical Structure
    RNF5-IN-1 Chemical Structure
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  • RNF5-IN-1