1807639-36-6
1807639-36-6
Chemical Structure
RNF5-IN-1
- CAS No.: 1807639-36-6
- Formula:C10H8O4S
- Molecular Weight:224.23
SMILES: O=C(C1=CC2=C(S1(=O)=O)C=CC=C2)OC
Biological Activity: RNF5-IN-1 (FX12) is a selective RNF5 degrader. RNF5-IN-1 binds to RNF5 and inhibits its E3 activity, and promotes proteasomal degradation of RNF5 in an endoplasmic reticulum (ER)-associated degradation (ERAD) way in cells. RNF5-IN-1 inhibits α-1-antitrypsin (NHK) dislocation with an IC50 value of 2.7 μM. RNF5-IN-1 can be used for research of cystic fibrosis, acute myeloid leukemia, and certain viral infections[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RNF5-IN-1 | 98.52% | RNF5-IN-1 (FX12) is a selective RNF5 degrader. RNF5-IN-1 binds to RNF5 and inhibits its E3 activity, and promotes proteasomal degradation of RNF5 in an endoplasmic reticulum (ER)-associated degradation (ERAD) way in cells. RNF5-IN-1 inhibits α-1-antitrypsin (NHK) dislocation with an IC50 value of 2.7 μM. RNF5-IN-1 can be used for research of cystic fibrosis, acute myeloid leukemia, and certain viral infections. | ||||||||||||||||||||
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References
Keywords
