(S)-YNT-3708
Based on 1 Customer Validation
(S)-YNT-3708, the S-enantiomer of YNT-3708, with low activity for OX1R and OX2R (EC50 = 3595 nM and 1661 nm, respectively).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.80%
- CAS 番号: 2923138-00-3
- 分子式: C35H36N4O6S
- 分子量:640.75
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Orexin Receptor (OX Receptor) アイソフォーム固有の製品をすべて表示
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生物活性
化学情報
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CAS 番号 2923138-00-3
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性状 Solid
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分子量 640.75
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分子式 C35H36N4O6S
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Color White to off-white
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SMILES
O=C(N(C)[C@H]1CCCC2=C1C=C(NS(=O)(C3=CC(/C=C/C(NC4=CC=NC=C4)=O)=CC=C3OC)=O)C=C2)CC5=CC=CC(OC)=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (156.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (7.80 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (269 KB)
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SDS (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5607 mL | 7.8034 mL | 15.6067 mL | 39.0168 mL |
| 5 mM | 0.3121 mL | 1.5607 mL | 3.1213 mL | 7.8034 mL | |
| 10 mM | 0.1561 mL | 0.7803 mL | 1.5607 mL | 3.9017 mL | |
| 15 mM | 0.1040 mL | 0.5202 mL | 1.0404 mL | 2.6011 mL | |
| 20 mM | 0.0780 mL | 0.3902 mL | 0.7803 mL | 1.9508 mL | |
| 25 mM | 0.0624 mL | 0.3121 mL | 0.6243 mL | 1.5607 mL | |
| 30 mM | 0.0520 mL | 0.2601 mL | 0.5202 mL | 1.3006 mL | |
| 40 mM | 0.0390 mL | 0.1951 mL | 0.3902 mL | 0.9754 mL | |
| 50 mM | 0.0312 mL | 0.1561 mL | 0.3121 mL | 0.7803 mL | |
| 60 mM | 0.0260 mL | 0.1301 mL | 0.2601 mL | 0.6503 mL | |
| 80 mM | 0.0195 mL | 0.0975 mL | 0.1951 mL | 0.4877 mL | |
| 100 mM | 0.0156 mL | 0.0780 mL | 0.1561 mL | 0.3902 mL |
(S)-YNT-3708 関連分類
HY-171032A 関連分類
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