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製品番号: HY-178338

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STING agonist-47

STING agonist-47 is a STING agonist with an EC₅₀ of 0.72 μM and a K_d of 176 nM. STING agonist-47 is a dimer of MSA-2 (HY-136927). STING agonist-47 can be used for the research of cancer, such as breast cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₈H₂₆O₈S₄
分子量:618.76

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

STING agonist-47 構造式

容量

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

STING agonist-47 (Compound SC2S) (0.71 μM, 24 h) activates the interferon pathway in THP-1 Lucia ISG cells^[1].
STING agonist-47 (5 μM, 0.5-4 h) treatment of THP-1 Lucia ISG cells leads to significantly increased phosphorylation levels of key STING pathway proteins (pSTING, pTBK1, pIRF3)^[1].
STING agonist-47 (25 μM, 6 h) induces IFN-β secretion in THP-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

STING agonist-47 (Compound SC2S) (0.62 μM, immersion administration, daily from 1 day post-infection to 4 for 3 consecutive days) inhibits tumor growth in 2-day-post-fertilization casper or nacre mutant zebrafish xenografted with Hs578T triple-negative breast cancer cells^[1].
STING agonist-47 (8.6 mg/kg, intratumoral injection) inhibits tumor growth in BALB/c mice inoculated with CT26mβGUS colon cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

2-day-post-fertilization (dpf) casper or nacre mutant zebrafish xenografted with Hs578T triple-negative breast cancer cells^[1]
Dosage:

0.62 μM
Administration:

Immersion administration, daily from 1 day post-infection to 4 for 3 consecutive days
Result:

Induced tumor cell apoptosis (activates Caspase3).
Reduced tumor size and increased the number of tumor-associated macrophages (TAM).
Promoted macrophage polarization to the proinflammatory M1 phenotype (expressing TNF).

化学情報

分子量 618.76
分子式 C₂₈H₂₆O₈S₄
SMILES

COC1=CC2=C(C=C1SCCSC3=CC4=C(SC(C(CCC(O)=O)=O)=C4)C=C3OC)C=C(S2)C(CCC(O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hsu NS, et al. Tumour-specific STING agonist synthesis via a two-component prodrug system. Nat Chem. 2025 Sep 16. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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