tDHU, acid
Based on 1 Customer Validation
tDHU, acid is a type of dihydropyrimidine Cereblon ligand and a benzoic acid linker conjugate, which can be used in the development of PROTACs.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.83%
- CAS 番号: 2377643-37-1
- 分子式: C12H12N2O4
- 分子量:248.23
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
E3 Ligase Ligand-Linker Conjugates アイソフォーム固有の製品をすべて表示
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生物活性
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Cereblon |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>50 μM
Compound: tDHU-CO2H
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Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay
Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay
|
[PMID: 35859867] |
| HEK293 | IC50 |
>50 μM
Compound: tDHU-CO2H
|
Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
|
[PMID: 35859867] |
| HEK293 | IC50 |
1.94 μM
Compound: tDHU-CO2H
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Cytotoxicity against permeabilized HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
Cytotoxicity against permeabilized HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
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[PMID: 35859867] |
tDHU, acid is a click chemistry reagent. tDHU, acid contains an Azide group, which can undergo a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. tDHU, acid can also undergo a ring tension-driven acetylene-azide cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2377643-37-1
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性状 Solid
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分子量 248.23
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分子式 C12H12N2O4
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Color White to off-white
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SMILES
O=C(C1=CC=C(C)C(N2C(NC(CC2)=O)=O)=C1)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 17.5 mg/mL (70.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0285 mL | 20.1426 mL | 40.2852 mL | 100.7131 mL |
| 5 mM | 0.8057 mL | 4.0285 mL | 8.0570 mL | 20.1426 mL | |
| 10 mM | 0.4029 mL | 2.0143 mL | 4.0285 mL | 10.0713 mL | |
| 15 mM | 0.2686 mL | 1.3428 mL | 2.6857 mL | 6.7142 mL | |
| 20 mM | 0.2014 mL | 1.0071 mL | 2.0143 mL | 5.0357 mL | |
| 25 mM | 0.1611 mL | 0.8057 mL | 1.6114 mL | 4.0285 mL | |
| 30 mM | 0.1343 mL | 0.6714 mL | 1.3428 mL | 3.3571 mL | |
| 40 mM | 0.1007 mL | 0.5036 mL | 1.0071 mL | 2.5178 mL | |
| 50 mM | 0.0806 mL | 0.4029 mL | 0.8057 mL | 2.0143 mL | |
| 60 mM | 0.0671 mL | 0.3357 mL | 0.6714 mL | 1.6786 mL |
tDHU, acid 関連分類
HY-W454906 関連分類
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