ZIKV-IN-1
ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 μM and EC90 of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- CAS 番号: 2762166-06-1
- 分子式: C21H18BrF2N3O3
- 分子量:478.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
EC50: 2.8 µM (ZIKV)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>50 μM
Compound: 38
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Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
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[PMID: 35306290] |
| Huh-7 | CC50 |
43.8 μM
Compound: 38
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Cytotoxicity against human Huh-7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
Cytotoxicity against human Huh-7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
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[PMID: 35306290] |
| SNB-19 | CC50 |
49.4 μM
Compound: 38
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Cytotoxicity against human SNB-19 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
Cytotoxicity against human SNB-19 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
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[PMID: 35306290] |
| Vero | CC50 |
46.8 μM
Compound: 38
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Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
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[PMID: 35306290] |
ZIKV-IN-1 (compound 38) (0-80 µM) shows anti-ZIKV activity in a dose-dependent manner in A549 cells[1].
ZIKV-IN-1 (5, 10, 25 µM; 48 h) decreases the expression of ZIKV E and cleaved caspase 3 protein[1].
ZIKV-IN-1 (1.25, 2.5, 5, 10, 20 µM; 0-250 s) shows strong affinity to ZIKV RdRp domain (Kd=1.87 µM) in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:0-50 µM
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Incubation Time:
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Result:Showed anti-ZIKV activity with an EC50 of 2.8 µM, EC90 of 6.8 µM, and CC50 of >50 µM.
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Cell Line:A549, Vero cells
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Concentration:5, 10, 25 µM
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Incubation Time:48 h
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Result:Decreased the expression of ZIKV E and cleaved caspase 3 protein.
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Cell Line:Vero, SNB19, Huh7, A549 cells
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Concentration:0-80 µM
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Incubation Time:
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Result:Showed low cytotoxicity with CC50s of 46.8, 49.4, 43.8, 54.1 µM for ZG01 strain of Vero, SNB19, Huh7, A549 cells, and CC50s of 470.5, 485.2, 512.8, 160.8 µM for MR766 strain of Vero, SNB19, Huh7, A549 cells, respectively.
化学情報
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CAS 番号 2762166-06-1
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分子量 478.29
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分子式 C21H18BrF2N3O3
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SMILES
CC1=NC=NC2=C1C(C#CC3=CC(F)=C(C=C3)Br)=CN2[C@@H]4O[C@@H]([C@H]([C@]4(F)C)O)CO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ZIKV-IN-1 関連分類
HY-146957 関連分類
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