Atp1a1 - ATPase, Na+/K+ transporting, alpha 1 polypeptide Gene

Also Known as Atpa-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11928

Summary

Enables P-type sodium:potassium-exchanging transporter activity and Phosphatase activity. Acts upstream of or within several processes, including negative regulation of glucocorticoid biosynthetic process; positive regulation of striated muscle contraction; and regulation of heart contraction. Located in several cellular components, including T-tubule; basolateral plasma membrane; and postsynaptic density. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a1 Products (1)

mRNA	Protein	Name
NM_144900.2	NP_659149.1	sodium/potassium-transporting ATPase subunit alpha-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables P-type potassium transmembrane transporter activity	IDA IDA: Inferred from direct assay	23229519	MGI
enables P-type sodium:potassium-exchanging transporter activity	IDA IDA: Inferred from direct assay	23229519	MGI
enables P-type sodium:potassium-exchanging transporter activity	IMP IMP: Inferred from mutant phenotype	10360172	MGI
enables phosphatase activity	IMP IMP: Inferred from mutant phenotype	10360172	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15485817	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	17408578	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of heart contraction	IMP IMP: Inferred from mutant phenotype	10360172	MGI
acts upstream of or within negative regulation of glucocorticoid biosynthetic process	IMP IMP: Inferred from mutant phenotype	17234593	MGI
acts upstream of or within negative regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	15485817	MGI
involved in osmosensory signaling pathway	IDA IDA: Inferred from direct assay	17408578	MGI
acts upstream of or within positive regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	10360172	MGI
acts upstream of or within positive regulation of striated muscle contraction	IMP IMP: Inferred from mutant phenotype	11507009	MGI
acts upstream of or within regulation of blood pressure	IGI IGI: Inferred from genetic interaction	16243970	MGI
acts upstream of or within regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	10360172	MGI
NOT involved in response to glycoside	IGI IGI: Inferred from genetic interaction	16243970	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	17234593	MGI
involved in sodium ion homeostasis	IDA IDA: Inferred from direct assay	17408578	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in T-tubule	IDA IDA: Inferred from direct assay	16292983	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21705333	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	8144700	MGI
located in membrane	IDA IDA: Inferred from direct assay	15755730	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	17408578	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10468580	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	15485817	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sodium/potassium-transporting ATPase subunit alpha-1	Na(+)/K(+) ATPase alpha-1 subunit sodium pump subunit alpha-1

Atp1a1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Atp1a1	Q8VDN2	Itpr1	Mus musculus	P11881	Anti Bait CoIP	16292983
Intra	Atp1a1	Q8VDN2	Slc8a1	Mus musculus	O35157	Anti Bait CoIP	16292983

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-Y0344D	Sodium chloride, for cell culture	Activator	99.9%	Phase 4
HY-12283	Rostafuroxin		98.02%	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2414	Periplogenin		≥99.70%	Unkown
HY-P2657	Verucopeptin	Inhibitor	97.0%	Unkown
HY-Y0344J	Sodium chloride, for molecular biology		99.97%	Unkown
HY-P1565A	Transdermal Peptide Disulfide TFA	Inhibitor	99.95%	Unkown
HY-Y0344I	Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al		99.99%	Unkown
HY-RS01182	ATP1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P1565	Transdermal Peptide Disulfide	Inhibitor	98.79%	Unkown
HY-RS16918	Atp1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01184	ATP1A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01185	ATP1A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01186	ATP1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-Y0344H	Sodium chloride, United States Pharmacopeia (USP) Reference Standard		/	Unkown
HY-RS21097	Atp1b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23361	Atp1a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27615	Atp1b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp1a1	NCBI	NCBI:476