HBP1 - HMG-box transcription factor 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26959

About HBP1

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:107,169,003-107,202,522 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele and 268 orthologues. Ubiquitous expression in thyroid (RPKM 32.0), endometrium (RPKM 26.6) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of lipid transport; negative regulation of Reactive Oxygen Species biosynthetic process; and negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Biomarker of osteoarthritis. [provided by Alliance of Genome Resources, Apr 2022]

HBP1 Products (2)

mRNA Protein Name
NM_001244262.2 NP_001231191.1 HMG box-containing protein 1 isoform 1
NM_012257.4 NP_036389.2 HMG box-containing protein 1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23859194 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HBP1 Protein Structure

AXH

AXH: Ataxin-1 and HBP1 module (AXH) (215 - 339)

HMG_box

HMG_box: HMG (high mobility group) box (435 - 499)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
Protein Preferred Names Protein Names

HMG box-containing protein 1

  • high mobility group box transcription factor 1

HBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HBP1 O60381 RB1 Homo sapiens P06400
Anti Bait CoIP
23859194
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HBP1 Proteins

Cat. No. Product Name Accession Purity
HY-P75150 HBP1 Protein, Human (His) O60381 (P208-F345) ≥ 95%, as determined by reducing SDS-PAGE.

HBP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811032 HBP1 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1165 Cyproheptadine (hydrochloride sesquihydrate) 99.74% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06033 HBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18616 Hbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25102 Hbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HBP1 RGD RGD:620444
Bos taurus HBP1 VGNC VGNC:29767
Canis familiaris HBP1 VGNC VGNC:41611
Felis catus HBP1 VGNC VGNC:62763
Macaca mulatta HBP1 VGNC VGNC:73218
Mus musculus HBP1 MGD MGI:894659
Others HBP1 NCBI