HBP1 Antibody
(Synonyms: HMG box-containing protein 1, HMG box transcription factor 1, High mobility group box transcription factor 1, HBP1)HBP1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to HBP1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
HBP1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to HBP1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 57; 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 57 kDa
Synthetic peptide corresponding to the C-term region of human HBP1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HBP1 is a Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
HBP1 has 3 isoforms, O60381-1: amino acid length is 514, molecular weight is 57645 Da (predicted); O60381-2: amino acid length is 462, molecular weight is 51433 Da (predicted); O60381-3: amino acid length is 514, molecular weight is 57699 Da (predicted).
Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation. -
Subunit
Binds the second PAH repeat of SIN3A (Probable).
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SwissProt ID
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Synonyms
HMG box-containing protein 1, HMG box transcription factor 1, High mobility group box transcription factor 1, HBP1
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