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Cat. No.: HY-N19877

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Neokadsuranic acid B

Neokadsuranic acid B is a 14 (13→12)-seco-lanostane-type triterpenoid acid that exists in the stems of Kadsura longipedunculata and Radix Aconiti Lateralis Preparata. It has high binding affinity for PTGS2 (COX-2). Neokadsuranic acid B shows promise for research into rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No.: 123828-59-1
Formula: C₃₀H₄₄O₃
Molecular Weight:452.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Neokadsuranic acid B Chemical Structure

CAS No.: 123828-59-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All COX Isoforms :

In Vitro

Neokadsuranic acid B shows high-affinity and stable binding to purified PTGS2 (COX-2) protein in molecular docking assay, with a binding energy of -8.5 kcal/mol and a stable RMSD value^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 123828-59-1
Molecular Weight 452.67
Formula C₃₀H₄₄O₃
SMILES

C[C@@]12C3=C(CC[C@@]1([H])C(C)(C(CC2)=O)C)[C@]4([C@@](C([C@@](CC4)([H])[C@H](C)CC/C=C(C)\C(O)=O)=C)([H])C3)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li L-n, et al. Triterpenoid Acids from Kadsura longipedunculata. Neokadsuranic Acids B and C: Two Novel Triterpenoids with 14 (13 → 12)abeo-Lanostane Skeletons. Planta Medica, 1989, 55(3): 294-296.

[2]. Chen P, et al. Comparative study of anti-inflammatory effects of different processed products through the COX-2/PGE2 signaling pathway: based on network pharmacology and molecular docking. Pharmacology Discovery, 2024, 4(2): 10.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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