Thiocoumarin
Thiocoumarin is a carbonic anhydrase (CA) inhibitor, with Ki values of 0.047 μM, 0.042 μM, and 0.1 μM against hCA IX, mCA XIII, and hCA I, respectively; its Ki values against hCA IV, mCA XV, hCA II, hCA VA, hCA VB, hCA VI, hCA VII, hCA XII, and hCA XIV are 4.1, 4.8, 6.2, 8.4, 7.5, 8.8, 7.3, 8.7, and 7.4 μM, respectively. As a photocage molecule, Thiocoumarin undergoes photolysis upon illumination to release the caged molecule, and it exhibits red-shifted absorption properties and rapid photolysis kinetics. Thiocoumarin can be used in cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 3986-98-9
- Formula: C9H6OS
- Molecular Weight:162.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Thiocoumarin-caged ATP is rapidly and cleanly uncaged to release ATP upon irradiation with 490 nm light (full release within 4 min at all tested intensities) or 400 nm light (full release within 30 s at 50% intensity) at a concentration of 1 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3986-98-9
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Molecular Weight 162.21
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Formula C9H6OS
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SMILES
S=C1OC2=C(C=C1)C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ma J, et al. Thiocoumarin Caged Nucleotides: Synthetic Access and Their Photophysical Properties. Molecules (Basel, Switzerland). 2020 Nov 15;25(22):5325. [Content Brief]
[2]. Maresca A, et al. Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. Journal of medicinal chemistry. 2010 Jan 14;53(1):335-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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