3986-98-9
Chemical Structure
Thiocoumarin
- CAS No.: 3986-98-9
- Formula:C9H6OS
- Molecular Weight:162.21
InChIKey: FRZDLTCXOSFHJC-UHFFFAOYSA-N
SMILES: S=C1OC2=C(C=C1)C=CC=C2
Biological Activity: Thiocoumarin is a carbonic anhydrase (CA) inhibitor, with Ki values of 0.047 μM, 0.042 μM, and 0.1 μM against hCA IX, mCA XIII, and hCA I, respectively; its Ki values against hCA IV, mCA XV, hCA II, hCA VA, hCA VB, hCA VI, hCA VII, hCA XII, and hCA XIV are 4.1, 4.8, 6.2, 8.4, 7.5, 8.8, 7.3, 8.7, and 7.4 μM, respectively. As a photocage molecule, Thiocoumarin undergoes photolysis upon illumination to release the caged molecule, and it exhibits red-shifted absorption properties and rapid photolysis kinetics. Thiocoumarin can be used in cancer-related research[1][2].
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Thiocoumarin | Thiocoumarin is a carbonic anhydrase (CA) inhibitor, with Ki values of 0.047 μM, 0.042 μM, and 0.1 μM against hCA IX, mCA XIII, and hCA I, respectively; its Ki values against hCA IV, mCA XV, hCA II, hCA VA, hCA VB, hCA VI, hCA VII, hCA XII, and hCA XIV are 4.1, 4.8, 6.2, 8.4, 7.5, 8.8, 7.3, 8.7, and 7.4 μM, respectively. As a photocage molecule, Thiocoumarin undergoes photolysis upon illumination to release the caged molecule, and it exhibits red-shifted absorption properties and rapid photolysis kinetics. Thiocoumarin can be used in cancer-related research. | |||||||||||||||||||||
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- [1]. Ma J, et al. Thiocoumarin Caged Nucleotides: Synthetic Access and Their Photophysical Properties. Molecules (Basel, Switzerland). 2020 Nov 15;25(22):5325. [Content Brief]
- [2]. Maresca A, et al. Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. Journal of medicinal chemistry. 2010 Jan 14;53(1):335-44. [Content Brief]
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