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Cat. No.: HY-W325160

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4-Chlorochalcone

고객리뷰

Based on 1 Customer Validation

4-Chlorochalcone (Compound 3) is a monoamine oxidase inhibitor (hMAO-B: IC₅₀ = 0.082 μM, hMAO-A: IC₅₀ = 9.95 μM). 4-Chlorochalcone also exhibits inhibitory activity against cholinesterase (AChE: IC₅₀ = 2.79 μM). 4-Chlorochalcone is a chalcone derivative.

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CAS No.: 956-04-7
화학식: C₁₅H₁₁ClO
분자량:242.70

보관:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Data Sheet (265 KB)

4-Chlorochalcone Chemical Structure

CAS No.: 956-04-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

All Cholinesterase (ChE) Isoforms :

AChE
BChE

Cellular Effect

Cell Line	Type	Value	Description	References
CAL-51	GI₅₀	5.85 μM Compound: SSE14105	Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay	[PMID: 28743509]
HCT-116	GI₅₀	16.54 μM Compound: SSE14105	Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay	[PMID: 28743509]
HepG2	IC₅₀	97.2 μM Compound: 2	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 22658085]
Neutrophil	IC₅₀	5.3 μM Compound: 2	Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method	[PMID: 33006891]
Neutrophil	IC₅₀	5.4 μM Compound: 2	Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method	[PMID: 33006891]
RBL-1	IC₅₀	85 μM Compound: 20	Inhibition of 5-lipoxygenase in rat RBL1 cells Inhibition of 5-lipoxygenase in rat RBL1 cells	10.1007/s00044-013-0745-7

Chemical Information

CAS No. 956-04-7
Appearance Solid
분자량 242.70
화학식 C₁₅H₁₁ClO
Color Off-white to light yellow
SMILES

O=C(C=CC1=CC=C(Cl)C=C1)C=2C=CC=CC2
선적

Room temperature in continental US; may vary elsewhere.

보관

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Oh JM, et al. Potent and selective inhibition of human monoamine oxidase-B by 4-dimethylaminochalcone and selected chalcone derivatives. Int J Biol Macromol. 2019 Sep 15;137:426-432. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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4-Chlorochalcone

All Monoamine Oxidase Isoforms

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

4-Chlorochalcone Related Classifications

HY-W325160 Related Classifications