Tolazamide
Based on 2 publication(s) in Google Scholar
Tolazamide (U-17835) is an orally active sulfonylurea agent that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (IC50 = 4.2 µM in HEK293 cells transfected with the human receptor). Tolazamide has anti-diabetic properties. Tolazamide can lower blood glucose in sulfonylurea class. Tolazamide decreases insulin dose while continuing to maintain adequate metabolic control. Tolazamide is able to improve or normalize hyperglycemia and HbA.
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- Purity: 99.94%
- CAS No.: 1156-19-0
- 화학식: C14H21N3O3S
- 분자량:311.40
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Tolazamide
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Biological Activity
Tolazamide (40-400 μg/mL, 1.5 h) attenuates ketogenesis (nanomoles of palmitate converted per min/mg DNA) from 5.2 to 3.5 and 2.7 with 40 and 400 μg/mL, respectively in the liver tissue of diabetic rats [4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1156-19-0
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Appearance Solid
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분자량 311.40
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화학식 C14H21N3O3S
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Color White to off-white
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SMILES
O=S(C1=CC=C(C)C=C1)(NC(NN2CCCCCC2)=O)=O
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Synonyms
U-17835
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
용액&용해도
DMSO : ≥ 39 mg/mL (125.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[2]. Gopalakrishnan, M., et al., (2000). Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells. British journal of pharmacology, 129(7), 1323–1332. [Content Brief]
[3]. Kabadi U. M. (1985). Adjuvant therapy with tolazamide and insulin improves metabolic control in type I diabetes mellitus. Diabetes care, 8(5), 440–446. [Content Brief]
[4]. McCormick, K., et al., (1986). Effect of tolazamide on basal ketogenesis, glycogenesis, and gluconeogenesis in liver obtained from normal and diabetic rats. Endocrinology, 119(3), 1268–1273. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2113 mL | 16.0565 mL | 32.1130 mL | 80.2826 mL |
| 5 mM | 0.6423 mL | 3.2113 mL | 6.4226 mL | 16.0565 mL | |
| 10 mM | 0.3211 mL | 1.6057 mL | 3.2113 mL | 8.0283 mL | |
| 15 mM | 0.2141 mL | 1.0704 mL | 2.1409 mL | 5.3522 mL | |
| 20 mM | 0.1606 mL | 0.8028 mL | 1.6057 mL | 4.0141 mL | |
| 25 mM | 0.1285 mL | 0.6423 mL | 1.2845 mL | 3.2113 mL | |
| 30 mM | 0.1070 mL | 0.5352 mL | 1.0704 mL | 2.6761 mL | |
| 40 mM | 0.0803 mL | 0.4014 mL | 0.8028 mL | 2.0071 mL | |
| 50 mM | 0.0642 mL | 0.3211 mL | 0.6423 mL | 1.6057 mL | |
| 60 mM | 0.0535 mL | 0.2676 mL | 0.5352 mL | 1.3380 mL | |
| 80 mM | 0.0401 mL | 0.2007 mL | 0.4014 mL | 1.0035 mL | |
| 100 mM | 0.0321 mL | 0.1606 mL | 0.3211 mL | 0.8028 mL |
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