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Cat. No.: HY-B0920R

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Tolazamide (Standard)

(Synonyms: U-17835 (Standard))

Tolazamide (U-17835) (Standard) is the analytical standard of Tolazamide. This product is intended for research and analytical applications. Tolazamide is an orally active sulfonylurea agent that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (IC₅₀ = 4.2 µM in HEK293 cells transfected with the human receptor). Tolazamide has anti-diabetic properties. Tolazamide can lower blood glucose in sulfonylurea class. Tolazamide decreases insulin dose while continuing to maintain adequate metabolic control. Tolazamide is able to improve or normalize hyperglycemia and HbA.

For research use only. We do not sell to patients.

CAS No.: 1156-19-0
Formula: C₁₄H₂₁N₃O₃S
Molecular Weight:311.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tolazamide (Standard) Chemical Structure

CAS No.: 1156-19-0

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Chemical Information
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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1156-19-0
Molecular Weight 311.40
Formula C₁₄H₂₁N₃O₃S
SMILES

O=S(C1=CC=C(C)C=C1)(NC(NN2CCCCCC2)=O)=O
Synonyms

U-17835 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Mustafa Karakaya, et al., (2015) Theoretical and experimental investigations on vibrational and structural properties of tolazamide, Journal of Molecular Structure, Volume 1095, Pages 87-95, ISSN 0022-2860.

[2]. Gopalakrishnan, M., et al., (2000). Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells. British journal of pharmacology, 129(7), 1323–1332. [Content Brief]

[3]. Kabadi U. M. (1985). Adjuvant therapy with tolazamide and insulin improves metabolic control in type I diabetes mellitus. Diabetes care, 8(5), 440–446. [Content Brief]

[4]. McCormick, K., et al., (1986). Effect of tolazamide on basal ketogenesis, glycogenesis, and gluconeogenesis in liver obtained from normal and diabetic rats. Endocrinology, 119(3), 1268–1273. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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