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Cat. No.: HY-P3779

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Amyloid 17-42

Name: Amyloid 17-42
Brand: MedChemExpress
SKU: HY-P3779
Availability: PreOrder

(Synonyms: Aβ(17-42))

Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway.

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CAS No.: 155178-13-5
화학식: C₁₁₉H₁₉₄N₂₈O₃₃S
분자량:2577.05

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Amyloid 17-42 Chemical Structure

CAS No.: 155178-13-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Amyloid 17-42 (20 μM; 48 h) leads to apoptosis in SH-SY5Y and IMR-32 cells^[1].
Amyloid 17-42 (20 μM; 48 h, 72 h) activates caspase-8 and caspase-3, induced poly(ADP-ribose) polymerase cleavage^[1].
Amyloid 17-42 (20 μM) moderately activates c-Jun N-terminal kinase (JNK)^[1].
Amyloid 17-42 induces neuronal apoptosis via a Fas-like/caspase-8 activation pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SH-SY5Y and IMR-32 cells
Concentration:

0-30 μM
Incubation Time:

48 h
Result:

Caused the death of SH-SY5Y and IMR-32 human neuroblastoma cells.

Apoptosis Analysis^[1]

Cell Line:

SH-SY5Y cells
Concentration:

20 μM
Incubation Time:

48 h
Result:

Showed shrunken cell bodies, condensed and fragmented chromatin, and increased amounts of cytoplasmic oligonucleosomes.

Western Blot Analysis^[1]

Cell Line:

SH-SY5Y cells
Concentration:

20 μM
Incubation Time:

48, 72 h; 18 h, 24 h
Result:

Reduced procaspase-3 and increased cleaved caspase-3 in cells.
Reduced procaspase-8 in cells.
Lead to early activation of JNK.

Chemical Information

CAS No. 155178-13-5
분자량 2577.05
화학식 C₁₁₉H₁₉₄N₂₈O₃₃S
Synonyms

Aβ(17-42)
Sequence Shortening

LVFFAEDVGSNKGAIIGLMVGGVVIA
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wanli Wei, et al. Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis. Brain. 2002 Sep;125(Pt 9):2036-43. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Minimum order quantity

100 mg

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