country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-149013

Copy Link Print Information

Anti-MRSA agent 5

Anti-MRSA agent 5 (B14) is a potent
MRSA
agent with MIC₅₀ values of 0.38 μg/mL and has low hERG activity with an IC₅₀ values of >40 μM. Anti-MRSA agent 5 (B14) also has low cytotoxicity to mammal cells and unlikely to acquire bacterial resistance.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2490154-44-2
화학식: C₂₅H₂₂N₄O₄
분자량:442.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anti-MRSA agent 5 Chemical Structure

CAS No.: 2490154-44-2

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

MIC: 0.38 μg/mL (MRSA); IC50: >40 Μm (hERG)

In Vitro

Anti-MRSA agent 5 (B14) is highly selective toxic in bacterial cells. Anti-MRSA agent has marginal inhibitory activities with an IC₅₀ values of exceeding 40 μM. Anti-MRSA agent 5 (B14) has strong antibacterial activity for all five clinical isolates of MRSA (NRS-1, NRS-70, NRS-100, NRS-108, NRS-271) with MIC values between < 0.17 and 0.69 μg/mL.Anti-MRSA agent 5 (B14) inhibits all three clinical isolates of fluoroquinolone-resistant MRSA (19-25, 19-26, 19-27) and exhibits good potency against VISA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line:

A549, MDA-MB-231, PC-3, ABAE.
Concentration:

0–400 μM
Incubation Time:

48h
Result:

Showed marginal inhibitory activities with anIC₅₀ exceeding 40 μM and displayed highly selective toxicity toward bacterial cells.

Chemical Information

CAS No. 2490154-44-2
분자량 442.47
화학식 C₂₅H₂₂N₄O₄
SMILES

O=C(C1=CN(C2CC2)C3=C(C=CC(NC4=NC=CC(OC5=CC=C(C)C(C)=C5)=N4)=C3)C1=O)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Runzhe Songa, et al, Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity, Bioorg Chem. 2020 Oct;103:104176. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기