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Cat. No.: HY-175937

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AR ligand-46

AR ligand-46 is an androgen receptor (AR) ligand that can be used in studies related to PROTAC synthesis, such as serving as a target protein ligand for A031 (HY-148777).

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CAS No.: 2682256-03-5
화학식: C₂₃H₂₅ClN₆O₂
분자량:452.94

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AR ligand-46 Chemical Structure

CAS No.: 2682256-03-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
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References
Calculators
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Biological Activity

제품 설명

AR ligand-46 is an androgen receptor (AR) ligand that can be used in studies related to PROTAC synthesis, such as serving as a target protein ligand for A031 (HY-148777)^[1].

In Vitro

AR ligand-46 serves as a target protein ligand for A031 (HY-148777), a PROTAC degrader targeting androgen receptor that induces time-dependent degradation of androgen receptor protein. A031 exerts tumor growth inhibitory effects on zebrafish models transplanted with human prostate cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2682256-03-5
분자량 452.94
화학식 C₂₃H₂₅ClN₆O₂
SMILES

O=C(N([C@@H]1C2)[C@H](CC1)C[C@@H]2OC3=CC(Cl)=C(C=C3)C#N)C4=CN=C(N5CCNCC5)N=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Chen L, et al. Discovery of A031 as effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer. European journal of medicinal chemistry. 2021 Apr 15;216:113307. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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