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Cat. No.: HY-119298

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AW-814141

AW-814141 is a selective and orally active p38 MAP kinase inhibitor. AW-814141 has an IC₅₀ values of 100 nM and 158 nM for p38-α and β isoforms, respectively. AW-814141 can inhibit the production of TNF-α induced by LPS (HY-D1056). AW-814141 can inhibit paw edema in rats in a dose-dependent manner. AW-814141 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases such as rheumatoid arthritis.

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CAS No.: 905285-51-0
화학식: C₂₂H₂₅N₅O
분자량:375.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AW-814141 Chemical Structure

CAS No.: 905285-51-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All p38 MAPK Isoforms :

Chemical Information

CAS No. 905285-51-0
분자량 375.47
화학식 C₂₂H₂₅N₅O
SMILES

O=C1C(C2=CC=CC=C2C)=CC3=CN=C(NN4CC5C(CCC5)C4)N=C3N1C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chopra P, et al. Pharmacological profile of AW-814141, a novel, potent, selective and orally active inhibitor of p38 MAP kinase. Int Immunopharmacol. 2010 Apr;10(4):467-73. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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AW-814141

All p38 MAPK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AW-814141 Related Classifications

HY-119298 Related Classifications