905285-51-0
Chemical Structure
AW-814141
- No. CAS: 905285-51-0
- Formula:C22H25N5O
- Molecular Weight:375.47
IUPAC Name: 2-((hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino)-8-methyl-6-(o-tolyl)pyrido[2,3-d]pyrimidin-7(8H)-one
InChIKey: KIZUENBEQYBJDB-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=CC=C2C)=CC3=CN=C(NN4CC5C(CCC5)C4)N=C3N1C
Biological Activity: AW-814141 is a selective and orally active p38 MAP kinase inhibitor. AW-814141 has an IC50 values of 100 nM and 158 nM for p38-α and β isoforms, respectively. AW-814141 can inhibit the production of TNF-α induced by LPS (HY-D1056). AW-814141 can inhibit paw edema in rats in a dose-dependent manner. AW-814141 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases such as rheumatoid arthritis[1].
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AW-814141 | AW-814141 is a selective and orally active p38 MAP kinase inhibitor. AW-814141 has an IC50 values of 100 nM and 158 nM for p38-α and β isoforms, respectively. AW-814141 can inhibit the production of TNF-α induced by LPS (HY-D1056). AW-814141 can inhibit paw edema in rats in a dose-dependent manner. AW-814141 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases such as rheumatoid arthritis. | |||||||||||||||||||||
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Keywords
