Brefonalol (hydrochloride)
Brefonalol (Brefanolol) hydrochloride is an orally active, non-selective β-adrenergic receptor blocker with vasodilatory properties. Brefonalol hydrochloride exhibits an optimal balance between β-blockade and vasodilatory effects at low doses: it reduces blood pressure and slows heart rate, while increasing stroke volume instead of decreasing it, causing no significant elevation in peripheral resistance and increasing reactive hyperemia; at high doses, the β-blockade effect dominates. Brefonalol hydrochloride can be used in the research of arterial hypertension.
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- CAS No.: 3026677-28-8
- 화학식: C22H29ClN2O2
- 분자량:388.93
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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β-adrenoceptor |
Brefonalol hydrochloride exhibits balanced β-receptor blocking and vasodilatory effects at a dose of 50 mg, while at a dose of 100 mg, it primarily exerts β-receptor blocking effects[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3026677-28-8
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Appearance Solid
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분자량 388.93
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화학식 C22H29ClN2O2
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SMILES
O=C1NC2=C(C=C(C(O)CNC(C)(C)CCC3=CC=CC=C3)C=C2)CC1.Cl
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Synonyms
Brefanolol hydrochloride
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Brefonalol (hydrochloride) Related Classifications
HY-113858A Related Classifications
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