CSF1R-IN-3
Based on 1 publication(s) in Google Scholar
CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity.
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- Purity: 98.10%
- CAS No.: 2760584-90-3
- 화학식: C30H38N8O4
- 분자량:574.67
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Covalent Screening Library
HY-L036
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Orally Active Compound Library
HY-L061
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Anti-Colorectal Cancer Compound Library
HY-L103
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Membrane Protein-targeted Compound Library
HY-L149
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Cytokine Inhibitors Library
HY-L161
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Macrophage Related Compound Library
HY-L174
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Covalent Screening Library Plus
HY-L036P
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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Protein Kinase Compound Library
HY-L196
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Cell Proliferation Compound Library
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
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Publications Citing Use of MedChemExpress (MCE) CSF1R-IN-3
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Biological Activity
Chemical Information
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CAS No. 2760584-90-3
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Appearance Solid
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분자량 574.67
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화학식 C30H38N8O4
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Color Yellow to orange
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SMILES
O=C1NC2=CC(NC(NC3=NOC(C(C)(C)C)=C3)=O)=CC=C2/C1=C/C4=C(C)C(NC(CN5CCN(C)CC5)=O)=C(C)N4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Commun Biol
RXFP2-positive mesenchymal stem cells in the antlerogenic periosteum contribute to postnatal development of deer antlers. [Abstract]2025 Apr 22;8(1):645. PMID: 40263536
용액&용해도
DMSO : 25 mg/mL (43.50 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7401 mL | 8.7006 mL | 17.4013 mL | 43.5032 mL |
| 5 mM | 0.3480 mL | 1.7401 mL | 3.4803 mL | 8.7006 mL | |
| 10 mM | 0.1740 mL | 0.8701 mL | 1.7401 mL | 4.3503 mL | |
| 15 mM | 0.1160 mL | 0.5800 mL | 1.1601 mL | 2.9002 mL | |
| 20 mM | 0.0870 mL | 0.4350 mL | 0.8701 mL | 2.1752 mL | |
| 25 mM | 0.0696 mL | 0.3480 mL | 0.6961 mL | 1.7401 mL | |
| 30 mM | 0.0580 mL | 0.2900 mL | 0.5800 mL | 1.4501 mL | |
| 40 mM | 0.0435 mL | 0.2175 mL | 0.4350 mL | 1.0876 mL |
CSF1R-IN-3 Related Classifications
HY-139990 Related Classifications
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