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Cat. No.: HY-W039750

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DAAO-IN-2

고객리뷰

Based on 1 Customer Validation

DAAO-IN-2 is a D-amino acid oxidase (DAAO) inhibitor, with an IC₅₀ of 0.123 μM against human DAAO and a K_d value of 1 μM against porcine DAAO. DAAO-IN-2 can be used for the research of schizophrenia.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 862274-39-3
화학식: C₇H₅FN₂O
분자량:152.13

보관:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

DAAO-IN-2 Chemical Structure

CAS No.: 862274-39-3

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재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Amino Acid Oxidase Isoforms :

D-Amino acid oxidase

In Vitro

DAAO-IN-2 has a pK_a of 7.84, with partial deprotonation at physiological and DAAO-optimal pH levels^[1].
DAAO-IN-2 (4 h) exhibits medium intestinal permeability in PAMPA testing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DAAO-IN-2 (30 mg/kg; i.p.; co-administered with 30 mg/kg D-Serine (HY-100808)) significantly increases plasma D-Serine levels in mice by 33% at 10 min and by 27% at 60 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NMRI mice (male, 25-30 g)^[1]
Dosage:

30 mg/kg
Administration:

i.p.; single co-administration with 30 mg/kg D-serine
Result:

Increased plasma D-serine levels by 33% at 10 minutes, with a corresponding plasma level of 13.1 μM for DAAO-IN-2.
Increased plasma D-serine levels by 27% at 60 minutes, with a corresponding plasma level of 0.77 μM for DAAO-IN-2.

Chemical Information

CAS No. 862274-39-3
Appearance Solid
분자량 152.13
화학식 C₇H₅FN₂O
SMILES

O=C1NNC2=CC(F)=CC=C12
선적

Room temperature in continental US; may vary elsewhere.

보관

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

순도&문서

Handling Instructions (2659 KB)

References

[1]. Szilágyi B, et al. Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors. Bioorg Med Chem. 2018 May 1;26(8):1579-1587. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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DAAO-IN-2

Amine Fragment Library

All Amino Acid Oxidase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DAAO-IN-2 Related Classifications

HY-W039750 Related Classifications