Amine Fragment Library

Cat. No.: HY-L236

PDF

Excel

SDF

Fragment-based drug discovery (FBDD) offers a strategic advantage by categorizing fragment hits according to their functional groups. This approach facilitates both the further optimization of these hits and the rational design of larger compounds through fragment combination. The amine functional group plays a vital role in drug development, as evidenced by its presence in many marketed drugs like Galantamine, Tacrine, and Rivastigmine. It is instrumental in enhancing solubility, improving bioavailability, and ensuring shelf-life stability—all critical factors for drug efficacy.

MCE offers a collection of 19,593 amine fragments for drug discovery. All of these compounds adhere to the Rule of Three (RO3) criteria for drug-likeness, which MCE offers a collection of 19,593 amine fragments for drug discovery, all of which stipulates a molecular weight ≤ 300 Da, ≤ 3 hydrogen bond donors, ≤ 3 hydrogen bond acceptors, and a cLogP ≤ 3.

Compound Screening Libraries

Download

Top Publications Citing Use of MedChemExpress (MCE) Products

Publications Citing Use of MedChemExpress (MCE) Products

Biological Activity
Product Details

Description & Advantages

• A unique collection of 19,593 amine fragment compounds for fragment-based drug discovery (FBDD).

• The fragemnts follow the Rule of Three.

• A useful tool for the fragment-based approach to drug discovery (FBDD).

• More detailed compound information with structure, Molecular Weight, cLogP, H-donor and H-acceptor number.

• NMR and HPLC validated ensure high purity.

• All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 19,593 amine fragment compounds supplied as pre-dissolved Solutions or Solid
Solution: 19,593 compounds supplied in 10 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal

Storage:

-80°C

Shipping:

Blue ice or dry ice

Documentation

PDF

Excel

Library Handling Instructions (351 KB)

Related Service
Recommendation

Compound Customization

Specific Compounds
Quantities
Plate Map
Concentration
Form (Solid or Solution)
YES

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Container *

Remarks