DHODH-IN-23
Based on 1 Customer Validation
DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for the research of cancer.
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- Purity: 98.75%
- CAS No.: 1346705-53-0
- 화학식: C24H21ClFNO4
- 분자량:441.88
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Ferroptosis Compound Library
HY-L051
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Orally Active Compound Library
HY-L061
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Anti-Blood Cancer Compound Library
HY-L079
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Mitochondria-Targeted Compound Library
HY-L089
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Metabolic Enzyme Compound Library
HY-L146
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Anti-Hematopathy Compound Library
HY-L171
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
DHODH-IN-23 (Compound A; 72 h) inhibits acute myeloid leukemia cells proliferation[1].
DHODH-IN-23 (0.1-3 μM; 72 h) induces CDllb expression in THP-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U937, HL-60, THP-1, KG-1 and MV411
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Concentration:
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Incubation Time:72 h
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Result:Inhibited cell growth with GI50s of 2.4, 2.5, 2.5, 3.5 and 7.6 μM against U937, THP-1, MV411 HL-60 and KG-1, respectively.
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Cell Line:THP-1 cells
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Concentration:72 h
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Incubation Time:0.1, 1 and 3 μM
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Result:Induced CDllb mRNA expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MV411 mouse xenograft model[1]
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Dosage:30 mg/kg
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Administration:Oral administration, twice daily for 21 days
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Result:Demonstrated significant anti-tumor activity both as a single agent and in combination with Cytarabine (HY-13605) at 20 mg/kg with tumor growth inhibitions of 37 and 73% respectively.
Chemical Information
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CAS No. 1346705-53-0
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Appearance Solid
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분자량 441.88
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화학식 C24H21ClFNO4
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Color White to off-white
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SMILES
O=C(C1=C(C(NC2=C(C=C(C3=CC=CC(OCCCC)=C3)C=C2Cl)F)=O)C=CC=C1)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 125 mg/mL (282.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2631 mL | 11.3153 mL | 22.6306 mL | 56.5764 mL |
| 5 mM | 0.4526 mL | 2.2631 mL | 4.5261 mL | 11.3153 mL | |
| 10 mM | 0.2263 mL | 1.1315 mL | 2.2631 mL | 5.6576 mL | |
| 15 mM | 0.1509 mL | 0.7544 mL | 1.5087 mL | 3.7718 mL | |
| 20 mM | 0.1132 mL | 0.5658 mL | 1.1315 mL | 2.8288 mL | |
| 25 mM | 0.0905 mL | 0.4526 mL | 0.9052 mL | 2.2631 mL | |
| 30 mM | 0.0754 mL | 0.3772 mL | 0.7544 mL | 1.8859 mL | |
| 40 mM | 0.0566 mL | 0.2829 mL | 0.5658 mL | 1.4144 mL | |
| 50 mM | 0.0453 mL | 0.2263 mL | 0.4526 mL | 1.1315 mL | |
| 60 mM | 0.0377 mL | 0.1886 mL | 0.3772 mL | 0.9429 mL | |
| 80 mM | 0.0283 mL | 0.1414 mL | 0.2829 mL | 0.7072 mL | |
| 100 mM | 0.0226 mL | 0.1132 mL | 0.2263 mL | 0.5658 mL |
DHODH-IN-23 Related Classifications
HY-153112 Related Classifications
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