Diquat dibromide
Based on 3 publication(s) in Google Scholar
Diquat dibromide is a comprehensive herbicide. Diquat dibromide increases the production of ROS and triggers mitochondrial Autophagy. Diquat dibromide generates free radicals such as superoxide anions through redox cycles, which induce oxidative stress. Diquat dibromide is cytotoxic, reproductive, and neurotoxic. Diquat dibromide is used in cotton, soybean, and other crops to combat noxious weeds.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.94%
- CAS No.: 85-00-7
- 화학식: C12H12Br2N2
- 분자량:344.05
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Diquat dibromide
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Biological Activity
Diquat dibromide (25 mg/L in drinking water; 10-week treatment) reduces beak red chroma and total plasma carotenoids, and increases lipophilic antioxidant capacity in adult male zebra finches[4].
Diquat (8-12 mg/kg; i.p.; twice a week; 4 weeks) dibromide causes reproductive toxicity in female mice[6].
Diquat (10 mg/kg; i.p.; twice a week; for 6 weeks) dibromide shows neurotoxic effects in male C57/BL-6 mice, inducing motor dysfunctions (such as bradykinesia, gait abnormalities, decreased swimming ability, etc.)[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Twelve male Duroc × Landrace × Yorkshire 35-d-old pigs (weaned at 21 d of age), with an average body weight of 9.6 kg, used as a model for studying the effect of Diquat-induced oxidative stress on intestinal barrier, mitochondrial function, and mitophagy[2].
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Dosage:10 mg/kg BW (dissolved in 0.9% NaCl solution)
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Administration:Intraperitoneal injection
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Result:Significantly decreased ADFI and ADG.
Impaired the intestinal barrier function, as indicated by a decrease in TER, an increase in FD4 flux, and a reduction in the protein abundance of claudin-1, occludin, and zonula occludens-1.
Caused mitochondrial dysfunction, with increased ROS production, decreased membrane potential in intestinal mitochondria, and a decrease in the mRNA abundance of genes related to mitochondrial biogenesis and function.
Triggered mitophagy, as shown by the increased expression of mitophagy-related proteins and the increased ratio of LC3-II to LC3-I.
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Animal Model:Female ICR mice[6]
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Dosage:8 mg/kg or 12 mg/kg (dissolved in normal saline)
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Administration:Intraperitoneal injection, twice a week, for 4 weeks
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Result:Significantly reduced ovary weights compared with control mice.
Decreased the percentage of normal GV oocytes and polar body extrusion.
Significantly increased ROS production in follicular granulosa cells and oocytes.
Decreased the activities of antioxidant enzymes (T-SOD, GPx and CAT) in the serum, and increased the MDA content.
Reduced the average numbers of fetus and litter size on GD 7.5 d.
Chemical Information
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CAS No. 85-00-7
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Appearance Solid
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분자량 344.05
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화학식 C12H12Br2N2
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Color Light yellow to brown
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SMILES
[N+]12=CC=CC=C1C3=[N+](CC2)C=CC=C3.[Br-].[Br-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Pestic Biochem Physiol
Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5/FOXO3a signaling pathway. [Abstract]2026 Jan;216(Pt 1):106728. PMID: 41326063 -
Biochem Biophys Res Commun
Alleviation effect of taxifolin on diquat-induced damage to porcine intestinal epithelial cells. [Abstract]2025 Feb 8:748:151318. PMID: 39826529 -
Biomed Pharmacother
Crocin-I mitigates diquat-induced pulmonary fibrosis via activation of the SIRT3/FOXO3a pathway. [Abstract]2025 Apr 6:186:118043. PMID: 40194334
용액&용해도
H2O : 5.83 mg/mL (16.95 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (283 KB)
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Handling Instructions (2659 KB)
References
[1]. Moreland D E. Mechanisms of action of herbicides. 1980.
[2]. Cao S, et al. Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets. J Anim Sci. 2018 May 4;96(5):1795-1805. [Content Brief]
[3]. Singh P, et al. Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. Parkinsons Dis. 2017;2017:2643587. [Content Brief]
[4]. Tomášek O, et al. Opposing effects of oxidative challenge and carotenoids on antioxidant status and condition-dependent sexual signalling. Sci Rep. 2016 Mar 22;6:23546. [Content Brief]
[5]. Nisar R, et al. Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria. Arch Toxicol. 2015 Oct;89(10):1811-25. [Content Brief]
[6]. Zhang JQ, et al. Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice. PLoS One. 2016 Jan 19;11(1):e0147075. [Content Brief]
[7]. Karuppagounder SS, et al. Investigate the chronic neurotoxic effects of diquat. Neurochem Res. 2012 May;37(5):1102-11. [Content Brief]
[8]. Acar A. In vivo toxicological assessment of diquat dibromide: cytotoxic, genotoxic, and biochemical approach. Environ Sci Pollut Res Int. 2021;28(34):47550-47561. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.9066 mL | 14.5328 mL | 29.0655 mL | 72.6639 mL |
| 5 mM | 0.5813 mL | 2.9066 mL | 5.8131 mL | 14.5328 mL | |
| 10 mM | 0.2907 mL | 1.4533 mL | 2.9066 mL | 7.2664 mL | |
| 15 mM | 0.1938 mL | 0.9689 mL | 1.9377 mL | 4.8443 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Diquat dibromide Related Classifications
HY-122984 Related Classifications
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