Diquat dibromide hydrate
Based on 3 publication(s) in Google Scholar
Diquat dibromide hydrate is a comprehensive herbicide. Diquat dibromide hydrate increases the production of ROS and triggers mitophagy. Diquat dibromide hydrate generates free radicals such as superoxide anions through redox cycles, which induce oxidative stress. Diquat dibromide hydrate is cytotoxic, reproductive, and neurotoxic. Diquat dibromide hydrate is used in cotton, soybean, and other crops to combat noxious weeds.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.95%
- CAS No.: 6385-62-2
- Formule: C12H14Br2N2O
- Masse moléculaire:362.06
-
Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Diquat dibromide hydrate
More
Activité biologique
Description
In Vitro
Diquat (10-20 μM; 20 h) dibromide hydrate causes cell death in SH-SY5Y cells[3].
Diquat (50 μM) dibromide hydrate induces axonal degeneration in cultured dorsal root ganglion (DRG) neurons[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Diquat dibromide hydrate (25 mg/L in drinking water; 10-week treatment) reduces beak red chroma and total plasma carotenoids, and increases lipophilic antioxidant capacity in adult male zebra finches[4].
Diquat (8-12 mg/kg; i.p.; twice a week; 4 weeks) dibromide hydrate causes reproductive toxicity in female mice[6].
Diquat (10 mg/kg; i.p.; twice a week; for 6 weeks) dibromide hydrate shows neurotoxic effects in male C57/BL-6 mice, inducing motor dysfunctions (such as bradykinesia, gait abnormalities, decreased swimming ability, etc.)[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Twelve male Duroc × Landrace × Yorkshire 35-d-old pigs (weaned at 21 d of age), with an average body weight of 9.6 kg, used as a model for studying the effect of Diquat-induced oxidative stress on intestinal barrier, mitochondrial function, and mitophagy[2].
-
Dosage:10 mg/kg BW (dissolved in 0.9% NaCl solution)
-
Administration:Intraperitoneal injection
-
Result:Significantly decreased ADFI and ADG.
Impaired the intestinal barrier function, as indicated by a decrease in TER, an increase in FD4 flux, and a reduction in the protein abundance of claudin-1, occludin, and zonula occludens-1.
Caused mitochondrial dysfunction, with increased ROS production, decreased membrane potential in intestinal mitochondria, and a decrease in the mRNA abundance of genes related to mitochondrial biogenesis and function.
Triggered mitophagy, as shown by the increased expression of mitophagy-related proteins and the increased ratio of LC3-II to LC3-I.
-
Animal Model:Female ICR mice[6]
-
Dosage:8 mg/kg or 12 mg/kg (dissolved in normal saline)
-
Administration:Intraperitoneal injection, twice a week, for 4 weeks
-
Result:Significantly reduced ovary weights compared with control mice.
Decreased the percentage of normal GV oocytes and polar body extrusion.
Significantly increased ROS production in follicular granulosa cells and oocytes.
Decreased the activities of antioxidant enzymes (T-SOD, GPx and CAT) in the serum, and increased the MDA content.
Reduced the average numbers of fetus and litter size on GD 7.5 d.
Chemical Information
-
CAS No. 6385-62-2
-
Appearance Solid
-
Masse moléculaire 362.06
-
Formule C12H14Br2N2O
-
Color Light yellow to yellow
-
SMILES
C12=CC=CC=[N+]1CC[N+]3=CC=CC=C23.[Br-].[Br-].O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Pestic Biochem Physiol
Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5/FOXO3a signaling pathway. [Abstract]2026 Jan;216(Pt 1):106728. PMID: 41326063 -
Biochem Biophys Res Commun
Alleviation effect of taxifolin on diquat-induced damage to porcine intestinal epithelial cells. [Abstract]2025 Feb 8:748:151318. PMID: 39826529 -
Biomed Pharmacother
Crocin-I mitigates diquat-induced pulmonary fibrosis via activation of the SIRT3/FOXO3a pathway. [Abstract]2025 May:186:118043. PMID: 40194334
Solvant et solubilité
In Vitro:
H2O : 125 mg/mL (345.25 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
-
Fiche technique (284 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Moreland D E. Mechanisms of action of herbicides. 1980. [Content Brief]
[2]. Nisar R, et al. Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria. Arch Toxicol. 2015 Oct;89(10):1811-25. [Content Brief]
[3]. Zhang JQ, et al. Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice. PLoS One. 2016 Jan 19;11(1):e0147075. [Content Brief]
[4]. Tomášek O, et al. Opposing effects of oxidative challenge and carotenoids on antioxidant status and condition-dependent sexual signalling. Sci Rep. 2016 Mar 22;6:23546. [Content Brief]
[5]. Singh P, et al. Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. Parkinsons Dis. 2017;2017:2643587. [Content Brief]
[6]. Cao S, et al. Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets. J Anim Sci. 2018 May 4;96(5):1795-1805. [Content Brief]
[7]. Acar A. In vivo toxicological assessment of Diquat dibromide hydrate: cytotoxic, genotoxic, and biochemical approach. Environ Sci Pollut Res Int. 2021;28(34):47550-47561. [Content Brief]
[8]. Moreland D E. Mechanisms of action of herbicides. 1980.
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.7620 mL | 13.8099 mL | 27.6197 mL | 69.0493 mL |
| 5 mM | 0.5524 mL | 2.7620 mL | 5.5239 mL | 13.8099 mL | |
| 10 mM | 0.2762 mL | 1.3810 mL | 2.7620 mL | 6.9049 mL | |
| 15 mM | 0.1841 mL | 0.9207 mL | 1.8413 mL | 4.6033 mL | |
| 20 mM | 0.1381 mL | 0.6905 mL | 1.3810 mL | 3.4525 mL | |
| 25 mM | 0.1105 mL | 0.5524 mL | 1.1048 mL | 2.7620 mL | |
| 30 mM | 0.0921 mL | 0.4603 mL | 0.9207 mL | 2.3016 mL | |
| 40 mM | 0.0690 mL | 0.3452 mL | 0.6905 mL | 1.7262 mL | |
| 50 mM | 0.0552 mL | 0.2762 mL | 0.5524 mL | 1.3810 mL | |
| 60 mM | 0.0460 mL | 0.2302 mL | 0.4603 mL | 1.1508 mL | |
| 80 mM | 0.0345 mL | 0.1726 mL | 0.3452 mL | 0.8631 mL | |
| 100 mM | 0.0276 mL | 0.1381 mL | 0.2762 mL | 0.6905 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Diquat dibromide hydrate Related Classifications
HY-136372 Related Classifications
Powered by Bioz