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Cat. No.: HY-128759

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DYRKs-IN-2

DYRKs-IN-2 (Example 132) is a potent DYRKs inhibitor with IC₅₀s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-2 has antitumor activity.

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CAS No.: 1386980-04-6
화학식: C₃₂H₃₈ClN₉O₃
분자량:632.16

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

DYRKs-IN-2 Chemical Structure

CAS No.: 1386980-04-6

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

DYRKs-IN-2 (Example 132) is a potent DYRKs inhibitor with IC₅₀s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-2 has antitumor activity^[1].

IC₅₀ & Target

IC50: 30.6 nM (DYRK1B) and 12.8 nM (DYRK1A)^[2]

All DYRK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SW-620	EC₅₀	0.18 μM Compound: 27	Cytotoxicity against human SW620 cells Cytotoxicity against human SW620 cells	[PMID: 24239188]

In Vitro

DYRKs-IN-2 (Example 132) has an EC₅₀ of 22.8 nM for SW620 cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1386980-04-6
분자량 632.16
화학식 C₃₂H₃₈ClN₉O₃
SMILES

O=C(C1=CC2=CN=C(NCCCN3CCN(C)CC3)N=C2NC1=O)NC4=CC(C(NC(C5=CC=CC=C5)CCN)=O)=CC=C4Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
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Purity:
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DYRKs-IN-2

All DYRK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DYRKs-IN-2 Related Classifications

HY-128759 Related Classifications