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Cat. No.: HY-W395779

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EBOV-IN-1

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.66%
CAS No.: 1335113-30-8
화학식: C₃₄H₄₃N₃O₅
분자량:573.72

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

EBOV-IN-1 Chemical Structure

CAS No.: 1335113-30-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
Publications (1)
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Bioz

Biological Activity

제품 설명

All Filovirus Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Vero C1008	IC₅₀	13 nM Compound: 3.47	Antiviral activity against VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs by fluorescence microsc Antiviral activity against VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs by fluorescence microsc	[PMID: 29920098]
Vero C1008	IC₅₀	64 nM Compound: 3.47	Antiviral activity against recombinant VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs in presence Antiviral activity against recombinant VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs in presence	[PMID: 29920098]

Chemical Information

CAS No. 1335113-30-8
Appearance Solid
분자량 573.72
화학식 C₃₄H₄₃N₃O₅
Color White to off-white
SMILES

COC(=O)C1=CC=C(COC2=CC=CC=C2CN2CCN(C(=O)CNC(=O)CC34CC5CC(CC(C5)C3)C4)CC2)C=C1
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Cell

Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018-2020 epidemic. [Abstract]

2026 Feb 5;189(3):818-831.e19. PMID: 41576953

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu H, et al. Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies. J Med Chem. 2018 Jul 26;61(14):6293-6307. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EBOV-IN-1

1 Cited Publications

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Publications (1)
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EBOV-IN-1

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) EBOV-IN-1

All Filovirus Isoforms

Biological Activity

Chemical Information

Publications (1)

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EBOV-IN-1

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) EBOV-IN-1

All Filovirus Isoforms

Biological Activity

Chemical Information

Publications (1)

순도&문서

References

Calculators

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EBOV-IN-1 Related Classifications

HY-W395779 Related Classifications