Esomeprazole hemistrontium
Based on 2 publication(s) in Google Scholar
Esomeprazole ((S)-Omeprazole) hemistrontium is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole hemistrontium has the potential for symptomatic gastroesophageal reflux disease research.
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- CAS No.: 914613-86-8
- 화학식: C17H18N3O3SSr+
- 분자량:388.22
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Publications Citing Use of MedChemExpress (MCE) Esomeprazole hemistrontium
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Biological Activity
Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) hemistrontium treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-468 cells
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Concentration:25 µM, 50 µM, 75 µM, 100 µM
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Incubation Time:20 hours
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Result:Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury[2]
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Dosage:30 mg/kg, 300 mg/kg
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Administration:Oral gavage; daily; for 19 or 11 days
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Result:Significantly inhibited the progression of fibrosis throughout the lungs of the animals.
Chemical Information
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CAS No. 914613-86-8
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분자량 388.22
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화학식 C17H18N3O3SSr+
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SMILES
O=[S@](C1=NC2=CC=C(OC)C=C2[N-]1)CC3=NC=C(C)C(OC)=C3C.[1/2].[Sr+2]
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Synonyms
(S)-Omeprazole hemistrontium; (-)-Omeprazole hemistrontium
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Inhibition of iron ion accumulation alleviates polystyrene nanoplastics-induced pulmonary fibroblast proliferation and activation. [Abstract]2025 Aug 13:164:115367. PMID: 40811949 -
순도&문서
References
[1]. Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46. [Content Brief]
[2]. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16. [Content Brief]
[3]. Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Esomeprazole hemistrontium Related Classifications
HY-17021C Related Classifications
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