GAK-IN-3
GAK-IN-3 is a cyclin G-associated kinase (GAK) inhibitor with an IC50 of 207 nM and a Ki of 66 nM. GAK-IN-3 inhibits kinase activity in the nanomolar range by binding to GAK’s ATP-binding site. GAK-IN-3 acts as a cytotoxic agent that reduces viability of Ewing sarcoma cells. GAK-IN-3 can be used for the research of ewing sarcoma.
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- 화학식: C19H19N5S
- 분자량:349.45
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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GAK 207 nM (IC50) |
GAK 66 nM (Ki) |
GAK-IN-3 (compound 3c) (10 μM; 48 h) reduces RD‐ES cell viability to 25.7% and Daoy cell viability to 44.6%[1].
GAK-IN-3 (compound 3c) (0.225-7.2 μM; 48 h) inhibits RD‐ES cell viability with an IC50 of 1.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RD‐ES (Ewing Sarcoma), Daoy (medulloblastoma)
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Concentration:10 μM
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Incubation Time:48 h
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Result:Reduced RD‐ES cell viability to 25.7% and Daoy cell viability to 44.6% at 10 μM after 48 h incubation.
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Cell Line:RD‐ES
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Concentration:7.2, 3.6, 1.8,
0.9, 0.45, and 0.225 μM -
Incubation Time:48 h
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Result:Inhibited RD‐ES cell viability with an IC50 of 1.1 μM after 48 h incubation.
Chemical Information
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분자량 349.45
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화학식 C19H19N5S
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SMILES
S=C(N)N/N=C/C1=CC=NC2=CC=C(NC3=CC(C)=CC(C)=C3)C=C21
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GAK-IN-3 Related Classifications
HY-181169 Related Classifications
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