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SGF29 - SAGA complex associated factor 29 Gene

Also Known as STAF36; TDRD29; CCDC101

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 112869

About SGF29

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,553,920-28,591,790 (from NCBI)

This gene has 7 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in testis (RPKM 13.2), ovary (RPKM 12.9) and 25 other tissues.

Summary

CCDC101 is a subunit of 2 Histone Acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

SGF29 Products (1)

mRNA	Protein	Name
NM_138414.3	NP_612423.1	SAGA-associated factor 29

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	20850016	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18838386	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19936620	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19103755	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22055187	GOA
involved in regulation of tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	20562830	GOA
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	23894581	GOA
involved in transcription initiation-coupled chromatin remodeling	IMP IMP: Inferred from mutant phenotype	23894581	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ATAC complex	IDA IDA: Inferred from direct assay	18838386	GOA
part of SAGA-type complex	IDA IDA: Inferred from direct assay	18838386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGF29 Protein Structure

DUF1325

0
100
200
293 a.a.

Protein Preferred Names	Protein Names
SAGA-associated factor 29	SAGA-associated factor 29 homolog

SGF29 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SGF29	Q96ES7	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
Intra	SGF29	Q96ES7	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	SGF29	Q96ES7	CLHC1	Homo sapiens	Q8NHS4	Y2H Array	25416956
Intra	SGF29	Q96ES7	CLHC1	Homo sapiens	Q8NHS4	Y2H Prey Pooling	25416956
Intra	SGF29	Q96ES7	SYCE3	Homo sapiens	A1L190	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	SYCE3	Homo sapiens	A1L190	Y2H Array	32296183
Intra	SGF29	Q96ES7	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	SGF29	Q96ES7	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	SGF29	Q96ES7	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	SGF29	Q96ES7	PROSER3	Homo sapiens	Q2NL68	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	PROSER3	Homo sapiens	Q2NL68	Y2H Array	32296183
Intra	SGF29	Q96ES7	TRAF3IP1	Homo sapiens	Q8TDR0-2	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	TRAF3IP1	Homo sapiens	Q8TDR0-2	Y2H Array	32296183
Intra	SGF29	Q96ES7	TEX12	Homo sapiens	Q9BXU0	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	TEX12	Homo sapiens	Q9BXU0	Validated Y2H	32296183
Intra	SGF29	Q96ES7	TEX12	Homo sapiens	Q9BXU0	Y2H Array	32296183
Intra	SGF29	Q96ES7	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	SGF29	Q96ES7	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	SGF29	Q96ES7	DBF4B	Homo sapiens	Q8NFT6-2	Y2H Array	32296183
Intra	SGF29	Q96ES7	DBF4B	Homo sapiens	Q8NFT6-2	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	SGF29	Q96ES7	KIF2C	Homo sapiens	Q99661	Anti Tag CoIP	33961781
Intra	SGF29	Q96ES7	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	MYF5	Homo sapiens	P13349	Y2H Array	32296183
Intra	SGF29	Q96ES7	C20orf202	Homo sapiens	A1L168	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	C20orf202	Homo sapiens	A1L168	Y2H Array	32296183
Intra	SGF29	Q96ES7	KRT24	Homo sapiens	Q2M2I5	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	KRT24	Homo sapiens	Q2M2I5	Y2H Array	32296183
Intra	SGF29	Q96ES7	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	SGF29	Q96ES7	SYNPO	Homo sapiens	Q8N3V7	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	SYNPO	Homo sapiens	Q8N3V7	Y2H Array	32296183
Intra	SGF29	Q96ES7	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	SGF29	Q96ES7	KNSTRN	Homo sapiens	Q9Y448	Y2H Array	32296183
Intra	SGF29	Q96ES7	KNSTRN	Homo sapiens	Q9Y448	Anti Tag CoIP	33961781
Intra	SGF29	Q96ES7	KNSTRN	Homo sapiens	Q9Y448	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	KNSTRN	Homo sapiens	Q9Y448	Validated Y2H	32296183
Intra	SGF29	Q96ES7	MED4	Homo sapiens	Q9NPJ6	Y2H Array	25416956
Intra	SGF29	Q96ES7	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	25416956
Intra	SGF29	Q96ES7	MED4	Homo sapiens	Q9NPJ6	Validated Y2H	25416956
Intra	SGF29	Q96ES7	MED11	Homo sapiens	Q9P086	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	MED11	Homo sapiens	Q9P086	Validated Y2H	32296183
Intra	SGF29	Q96ES7	MED11	Homo sapiens	Q9P086	Y2H Array	32296183
Intra	SGF29	Q96ES7	TADA3	Homo sapiens	O75528	Anti Tag CoIP	33961781
Intra	SGF29	Q96ES7	TADA3	Homo sapiens	O75528	TAP	24981860
Intra	SGF29	Q96ES7	TADA3	Homo sapiens	O75528	Anti Tag CoIP	28514442
Intra	SGF29	Q96ES7	TADA3	Homo sapiens	O75528	Validated Y2H	25416956
Intra	SGF29	Q96ES7	TADA3	Homo sapiens	O75528	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	TADA3	Homo sapiens	O75528	Anti Tag CoIP	26496610
Intra	SGF29	Q96ES7	TADA3	Homo sapiens	O75528	Y2H Array	25416956
Intra	SGF29	Q96ES7	TADA3	Homo sapiens	O75528	Y2H Array	32296183
Intra	SGF29	Q96ES7	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	SGF29	Q96ES7	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	SGF29	Q96ES7	TCF4	Homo sapiens	P15884	Anti Tag CoIP	33961781
Intra	SGF29	Q96ES7	NDC80	Homo sapiens	O14777	Y2H Prey Pooling	25416956
Intra	SGF29	Q96ES7	NDC80	Homo sapiens	O14777	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	NDC80	Homo sapiens	O14777	Anti Tag CoIP	33961781
Intra	SGF29	Q96ES7	NDC80	Homo sapiens	O14777	Y2H Array	32296183
Intra	SGF29	Q96ES7	NDC80	Homo sapiens	O14777	Y2H Array	25416956
Intra	SGF29	Q96ES7	NDC80	Homo sapiens	O14777	MAPPIT	25416956
Intra	SGF29	Q96ES7	ITPRID2	Homo sapiens	P28290	Anti Tag CoIP	33961781
Intra	SGF29	Q96ES7	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	31515488
Intra	SGF29	Q96ES7	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	25416956
Intra	SGF29	Q96ES7	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	25416956
Intra	SGF29	Q96ES7	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	SGF29	Q96ES7	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	SGF29	Q96ES7	KRT15	Homo sapiens	P19012	Y2H Array	25416956
Intra	SGF29	Q96ES7	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	SGF29	Q96ES7	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	SGF29	Q96ES7	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	H3C1	Homo sapiens	P68431	X-Ray Diffraction	21685874
Intra	SGF29	Q96ES7	H3C1	Homo sapiens	P68431	FPS	21685874
Intra	SGF29	Q96ES7	H3C1	Homo sapiens	P68431	ITC	21685874
Intra	SGF29	Q96ES7	BECN1	Homo sapiens	Q14457	Y2H Array	32296183
Intra	SGF29	Q96ES7	BECN1	Homo sapiens	Q14457	Y2H Prey Pooling	32296183
Intra	SGF29	Q96ES7	BECN1	Homo sapiens	Q14457	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-158009	SGF29-IN-1	Inhibitor	98.0%	Unkown
HY-RS12796	SGF29 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W657887	GSK-3β/G9a-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SGF29	RGD	RGD:1310609
Macaca mulatta	SGF29	VGNC	VGNC:97827
Mus musculus	SGF29	MGD	MGI:1922815
Bos taurus	SGF29	VGNC	VGNC:97311
Felis catus	SGF29	VGNC	VGNC:97623
Canis familiaris	SGF29	VGNC	VGNC:97220
Others	SGF29	NCBI