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  4. SGF29-IN-1

SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)–associated factor 29 (SGF29)-Tudor domain. SGF29-IN-1 exhibits activity against leukemia.

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SGF29-IN-1 Chemical Structure

SGF29-IN-1 Chemical Structure

CAS No. : 6638-82-0

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SGF29-IN-1 Related Antibodies

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Description

SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)–associated factor 29 (SGF29)-Tudor domain. SGF29-IN-1 exhibits activity against leukemia[1].

In Vitro

SGF29-IN-1 (20 μM) inhibits Tudor domain of SGF29, blocks acetylation of H3K9 in SGF29-dependent leukemia cells MOLM13 and MV4-11[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SGF29-IN-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: MOLM13 and MV4-11
Concentration: 20 μM
Incubation Time: 48 h
Result: Inhibited acetylation of H3K9 and levels of RPL8 and RPS2.
In Vivo

SGF29-IN-1 (5 mg/kg, i.p. every other day for 35 days) inhibits leukemia progression without significant toxicity in CD45 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MLL-AF9 xenograft CD45 mice[1]
Dosage: 5 mg/kg
Administration: i.p., every other day for 35 days
Result: Reduced percentage of 45.2 cells in peripheral blood and spleen. Improved survival rate of rats.
Molecular Weight

519.63

Formula

C33H33N3O3
CAS No.
SMILES

C1(CN2COC3=C(C2)C4=C(CN(CC5=CC=CC=C5)CO4)C6=C3CN(CO6)CC7=CC=CC=C7)=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SGF29-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGF29-IN-16638-82-0OthersLeukemiatudor domainMOLM13MV4-11CD45 mouseInhibitorinhibitorinhibit

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