Fabp5 - fatty acid binding protein 5, epidermal Gene

Also Known as Klbp; mal1; Fabpe; E-FABP; PA-FABP

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16592

Summary

The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and Other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, Insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013]

Fabp5 Products (3)

mRNA	Protein	Name
NM_001272097.1	NP_001259026.1	fatty acid-binding protein 5 isoform 2
NM_001272098.1	NP_001259027.1	uncharacterized protein LOC16592 isoform 3
NM_010634.3	NP_034764.1	fatty acid-binding protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables retinoic acid binding	IDA IDA: Inferred from direct assay	17512406	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	12540600	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	12540600	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	12540600	MGI
acts upstream of or within negative regulation of D-glucose transmembrane transport	IMP IMP: Inferred from mutant phenotype	12540600	MGI
acts upstream of or within phosphatidylcholine biosynthetic process	IGI IGI: Inferred from genetic interaction	15164767	MGI
involved in positive regulation of cold-induced thermogenesis	IGI IGI: Inferred from genetic interaction	24603714	MGI
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17512406	MGI
involved in regulation of prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	29440395	MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid	IDA IDA: Inferred from direct assay	29531087	MGI
involved in regulation of sensory perception of pain	IMP IMP: Inferred from mutant phenotype	29440395	MGI
involved in retrograde trans-synaptic signaling by endocannabinoid	EXP EXP: Inferred from Experiment	29531087	MGI
involved in retrograde trans-synaptic signaling by endocannabinoid	IDA IDA: Inferred from direct assay	29531087	MGI
involved in retrograde trans-synaptic signaling by endocannabinoid	IMP IMP: Inferred from mutant phenotype	29531087	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17512406	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	29531087	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	29531087	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	29531087	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	29531087	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17512406	MGI
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	29531087	MGI
is active in postsynaptic cytosol	IMP IMP: Inferred from mutant phenotype	29531087	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	29531087	MGI
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	29531087	MGI
is active in postsynaptic density, intracellular component	IMP IMP: Inferred from mutant phenotype	29531087	MGI
located in synapse	IDA IDA: Inferred from direct assay	29531087	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
fatty acid-binding protein 5 uncharacterized protein LOC16592	epidermal-type fatty acid-binding protein epithelial fatty acid-binding protein fatty acid-binding protein, epidermal keratinocyte lipid-binding protein psoriasis-associated fatty acid-binding protein homolog

Protein Preferred Names

Protein Names

fatty acid-binding protein 5

uncharacterized protein LOC16592

epidermal-type fatty acid-binding protein
epithelial fatty acid-binding protein
fatty acid-binding protein, epidermal
keratinocyte lipid-binding protein
psoriasis-associated fatty acid-binding protein homolog

Recombinant Fabp5 Proteins

Cat. No.	상품명	Accession	Purity
HY-P79398	FABP5 Protein, Mouse (His)	Q05816 (M1-Q135)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-101903	BMS-309403	Inhibitor	99.91%	Unkown
HY-101903A	BMS-309403 sodium	Inhibitor	99.89%	Unkown
HY-145990	FABPs ligand 6	Inhibitor	99.86%	Unkown
HY-161702	RO6806051	Inhibitor	99.82%	Unkown
HY-160457	FABP4/5-IN-5	Inhibitor	98.10%	Unkown
HY-N8144	Niga-ichigoside F1		99.0%	Unkown
HY-RS04661	FABP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-178471	FABP4/5-IN-6	Inhibitor	/	Unkown
HY-183836	FABP4/5-IN-7	Inhibitor	/	Unkown
HY-160456	FABP4/5-IN-4	Inhibitor	/	Unkown
HY-RS16605	Fabp5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23039	Fabp5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fabp5	NCBI	NCBI:2171