EIF3K - eukaryotic translation initiation factor 3 subunit K Gene

Also Known as M9; ARG134; PLAC24; PTD001; EIF3S12; HSPC029; MSTP001; PLAC-24; PRO1474; EIF3-p28

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27335

About EIF3K

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,619,188-38,636,954 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 209 orthologues. Ubiquitous expression in heart (RPKM 136.4), duodenum (RPKM 100.7) and 25 other tissues.

Summary

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]

EIF3K Products (3)

mRNA Protein Name
NM_001300992.2 NP_001287921.1 eukaryotic translation initiation factor 3 subunit K isoform 2
NM_001308393.2 NP_001295322.1 eukaryotic translation initiation factor 3 subunit K isoform 3
NM_013234.4 NP_037366.1 eukaryotic translation initiation factor 3 subunit K isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
contributes to translation initiation factor activity IDA
IDA: Inferred from direct assay
17581632 GOA
Biological Process GO Annotation Evidence References Source
involved in translational initiation IDA
IDA: Inferred from direct assay
17581632 GOA
Cellular Component GO Annotation Evidence References Source
part of eukaryotic translation initiation factor 3 complex IDA
IDA: Inferred from direct assay
17322308 GOA
part of eukaryotic translation initiation factor 3 complex IPI
IPI: Inferred from physical interaction
17322308 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3K Protein Structure

CSN8_PSD8_EIF3K

CSN8_PSD8_EIF3K: CSN8/PSMD8/EIF3K family (62 - 200)

  • 0
  • 100
  • 200
  • 218 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 3 subunit K

  • eIF-3 p28

EIF3K Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF3K Q9UBQ5 EIF3E Homo sapiens P60228
Anti Tag CoIP
35271311
Intra
EIF3K Q9UBQ5 EIF3E Homo sapiens P60228
Pull Down
23623729
Intra
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262
SLCA
18599441
Intra
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262
Y2H
21516116
Intra
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262
Y2H Pooling
16189514
Intra
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262
Validated Y2H
32296183
Intra
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262
Anti Tag CoIP
35271311
Intra
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262
Pull Down
23623729
Intra
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262
Y2H Array
25416956
Cross
EIF3K Q9UBQ5 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF3K Proteins

Cat. No. 상품명 Accession Purity
HY-P76901 EIF3K Protein, Human (sf9, His-GST) Q9UBQ5 (A2-Q218) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 11

  • Hypertrophic Cardiomyopathy 11

  • CMH11

  • Cardiomyopathy, Hypertrophic, 11

  • Cardiomyopathy Familial Hypertrophic 11

  • Cardiomyopathy, Familial Hypertrophic 11

  • Cardiomyopathy, Hypertrophic, Familial, Type 11
Arthrogryposis, Distal, Type 1a

  • Distal Arthrogryposis Type 1

  • Digitotalar Dysmorphism

  • DA1A

  • Da1

  • Amcd1

  • Arthrogryposis, Distal, Type 2b4

  • Distal Arthrogryposis Type 1a

  • Arthrogryposis, Distal, Type 1

  • Arthrogryposis Multiplex Congenita Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal, Type I

  • Distal Arthrogryposis Type 1b

  • Arthrogryposis, Distal, 1a

  • Amc

  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis, Distal, 2b4

  • DA2B4

  • Arthrogryposis Multiplex Congenita, Distal, Type 1

  • Arthrogryposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS04267 EIF3K Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20014 Eif3k Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26517 Eif3k Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EIF3K MGD MGI:1921080
Canis familiaris EIF3K VGNC VGNC:40277
Rattus norvegicus EIF3K RGD RGD:1309221
Macaca mulatta EIF3K VGNC VGNC:72102
Felis catus EIF3K VGNC VGNC:61785
Bos taurus EIF3K VGNC VGNC:28401
Others EIF3K NCBI