KIF22 - kinesin family member 22 Gene

Also Known as KID; OBP; KNSL4; OBP-1; OBP-2; SEMDJL2; A-328A3.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3835

About KIF22

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,790,751-29,805,385 (from NCBI)

This gene has 33 transcripts (splice variants), 179 orthologues, 41 paralogues and is associated with 3 phenotypes. Broad expression in bone marrow (RPKM 24.9), testis (RPKM 13.3) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

KIF22 Products (3)

mRNA	Protein	Name
NM_001256269.2	NP_001243198.1	kinesin-like protein KIF22 isoform 2
NM_001256270.1	NP_001243199.1	kinesin-like protein KIF22 isoform 2
NM_007317.3	NP_015556.1	kinesin-like protein KIF22 isoform 1

KIF22 Protein Structure

Kinesin

HHH_3

0
200
400
600
665 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF22	kinesin-like DNA-binding protein pseudogene

KIF22 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P82753	Phospho-KIF22 (Ser427) Antibody (YA2498)	WB	Human
HY-P82753A	Phospho-KIF22 (Ser427) Antibody (YA2498)(PBS only)	WB	Human
HY-P84576	KIF22 Antibody (YA4273)	IHC-P, FC, ELISA	Human
HY-P84576A	KIF22 Antibody (YA4273)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2	SEMDJL2 Spondyloepimetaphyseal Dysplasia With Joint Laxity, Leptodactylic Type Spondyloepimetaphyseal Dysplasia With Multiple Dislocations, Hall Type Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 2 Spondyloepimetaphyseal Dysplasia With Multiple Dislocations Hall Type Spondyloepimetaphyseal Dysplasia With Joint Laxity, Hall Type Semd-Md Spondyloepimetaphyseal Dysplasia With Joint Laxicity, Hall Type Spondyloepimetaphyseal Dysplasia With Joint Laxity, 2 Lepto-Semdjl Spondyloepimetaphyseal Dysplasia With Joint Laxity Hall Type Spondyloepimetaphyseal Dysplasia With Joint Laxity Leptodactylic Type Spondyloepimetaphyseal Dysplasia With Multiple Dislocations
Spondyloepimetaphyseal Dysplasia With Multiple Dislocations	Spondyloepimetaphyseal Dysplasia With Multiple Dislocations Hall Type Spondyloepimetaphyseal Dysplasia With Multiple Dislocations Leptodactylic Type Semd-Md Semdjl2 Spondyloepimetaphyseal Dysplasia With Joint Laxicity, Hall Type Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 2 Spondyloepimetaphyseal Dysplasia With Joint Laxity, Leptodactylic Type Spondyloepimetaphyseal Dysplasia With Multiple Dislocations, Hall Type
Spondyloepimetaphyseal Dysplasia With Joint Laxity	Dysplasia, Spondyloepimetaphyseal, With Joint Laxity Semdjl Spondyloepimetaphyseal Dysplasia Joint Laxity Semd-Jl Semdjl1 Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 1 Spondyloepimetaphyseal Dysplasia With Joint Laxity, Beighton Type
Spondyloepimetaphyseal Dysplasia	Dysplasia, Spondyloepimetaphyseal
Spondylocostal Dysostosis 5	Spondylothoracic Dysostosis SCDO5 Jarcho-Levin Syndrome Scoliosis, Congenital, With Or Without Rib Anomalies Tacs Spondylocostal Dysplasia Costovertebral Segmentation Anomalies Spondylocostal Dysostosis 1 Spondylocostal Dysostosis Spondylothoracic Dysplasia Scdo1 Spondylocostal Dysostosis 1 Autosomal Recessive Costovertebral Dysplasia Scdo Std Autosomal Dominant Spondylocostal Dysostosis Autosomal Dominant Spondylocostal Dysplasia Doid:0112363 Spondylocostal Dysostosis 4, Autosomal Dominant
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Spondylocostal Dysostosis	Jarcho-Levin Syndrome Costovertebral Dysplasia Spondylothoracic Dysostosis Spondylothoracic Dysplasia Scdo Dysostosis, Spondylocostal
Scoliosis
Benign Familial Infantile Epilepsy	Benign Familial Infantile Seizures Bfie Benign Familial Infantile Convulsion Bfic Bfis Benign Familial Infantile Convulsions Familial Benign Neonatal Epilepsy Watanabe-Vigevano Syndrome
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS07276	KIF22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21617	Kif22 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28135	Kif22 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KIF22	VGNC	VGNC:30596
Canis familiaris	KIF22	VGNC	VGNC:42398
Felis catus	KIF22	VGNC	VGNC:67973
Rattus norvegicus	KIF22	RGD	RGD:1311886
Mus musculus	KIF22	MGD	MGI:109233
Macaca mulatta	KIF22	VGNC	VGNC:74033
Others	KIF22	NCBI