REN - renin Gene
Also Known as RTD; HNFJ2; ADTKD4
Species: Homo sapiens
About REN
This gene has 2 transcripts (splice variants), 220 orthologues, 9 paralogues and is associated with 4 phenotypes.
Summary
This gene encodes Renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of Angiotensinogen by cleaving Angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis. [provided by RefSeq, May 2020]
REN Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_000537.4 | NP_000528.1 | renin preproprotein |
| NM_000537.4 | NP_000528.1 | renin preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables aspartic-type endopeptidase activity |
EXP
EXP: Inferred from Experiment
|
4289389 | GOA |
| enables aspartic-type endopeptidase activity |
IDA
IDA: Inferred from direct assay
|
12045255 | GOA |
| enables peptidase activity |
IDA
IDA: Inferred from direct assay
|
12045255 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
20927107 | GOA |
| enables signaling receptor binding |
IPI
IPI: Inferred from physical interaction
|
12045255 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in angiotensin maturation |
IDA
IDA: Inferred from direct assay
|
12045255 | GOA |
| involved in kidney development |
IMP
IMP: Inferred from mutant phenotype
|
16116425 | GOA |
| involved in proteolysis |
IDA
IDA: Inferred from direct assay
|
12045255 | GOA |
| involved in regulation of MAPK cascade |
IDA
IDA: Inferred from direct assay
|
12045255 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in apical part of cell |
IDA
IDA: Inferred from direct assay
|
26322847 | GOA |
| is active in extracellular space |
IDA
IDA: Inferred from direct assay
|
12045255 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
12045255 | GOA |
REN Protein Structure
A1_Propeptide: A1 Propeptide (33 - 56)
Asp: Eukaryotic aspartyl protease (85 - 404)
- 0
- 100
- 200
- 300
- 406 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
renin |
|
|
REN Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
REN | P00797 | AGT | Homo sapiens | P01019 | 20927107 | |
|
Intra
|
REN | P00797 | AGT | Homo sapiens | P01019 | 20927107 |
Recombinant REN Proteins
| Cat. No. | 상품명 | Accession | Purity |
|---|---|---|---|
| HY-P71052 | Renin Protein, Human (HEK293, His) | P00797-1 (L24-R406) | ≥ 95%, as determined by reducing SDS-PAGE. |
REN Antibodies
| Cat. No. | 상품명 | 신청 | Reactivity |
|---|---|---|---|
| HY-P82982 | Renin Antibody (YA2727) | WB, FC | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Renal Tubular Transport Disease |
|
|
| Diastolic Heart Failure |
|
|
| Diabetic Autonomic Neuropathy |
|
|
| Pseudohypoaldosteronism, Type I, Autosomal Dominant |
|
|
| Bartter Disease |
|
|
| Glucose Metabolism Disease |
|
|
| Multicystic Dysplastic Kidney |
|
|
| Sleep Disorder |
|
|
| Aortic Valve Disease 2 |
|
|
| Cerebrovascular Disease |
|
|
| Acute Pulmonary Heart Disease |
|
|
| Apparent Mineralocorticoid Excess |
|
|
| Diabetes Insipidus, Neurohypophyseal |
|
|
| Supine Hypotensive Syndrome |
|
|
| Heart Valve Disease |
|
|
| Kidney Papillary Necrosis |
|
|
| Adrenal Cortex Disease |
|
|
| Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease |
|
|
| Systolic Heart Failure |
|
|
| Dilated Cardiomyopathy |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Urinary Tract Infection |
|
|
| Inherited Metabolic Disorder |
|
|
| Liver Cirrhosis |
|
|
| Pyelitis |
|
|
| Myocardial Infarction |
|
|
| Pericardial Effusion |
|
|
| Renal Hypertension |
|
|
| Aortic Valve Disease 1 |
|
|
| Cell Type Benign Neoplasm |
|
|
| Peripheral Nervous System Disease |
|
|
| Paraganglioma |
|
|
| Gitelman Syndrome |
|
|
| Coronary Artery Vasospasm |
|
|
| Hydronephrosis |
|
|
| Hypertensive Retinopathy |
|
|
| Adrenal Cortical Adenoma |
|
|
| Adrenal Cortical Hypofunction |
|
|
| Placenta Disease |
|
|
| Liddle Syndrome 1 |
|
|
| Mitral Valve Stenosis |
|
|
| Adenoma |
|
|
| Acute Myocarditis |
|
|
| Parathyroid Gland Disease |
|
|
| Adrenal Carcinoma |
|
|
| Space Motion Sickness |
|
|
| Renal Artery Disease |
|
|
| Peripheral Artery Disease |
|
|
| Hypoadrenocorticism, Familial |
|
|
| Abetalipoproteinemia |
|
|
| Interstitial Nephritis |
|
|
| Membranoproliferative Glomerulonephritis |
|
|
| Retinal Vascular Disease |
|
|
| Diabetes Insipidus |
|
|
| Vascular Disease |
|
|
| Mitral Valve Insufficiency |
|
|
| Peripheral Vascular Disease |
|
|
| Hyperthyroidism |
|
|
| Hyperuricemia |
|
|
| Inappropriate Adh Syndrome |
|
|
| Intracranial Berry Aneurysm |
|
|
| Acquired Metabolic Disease |
|
|
| Severe Covid-19 |
|
|
| Diarrhea |
|
|
| Fibromuscular Dysplasia |
|
|
| Uremic Neuropathy |
|
|
| Severe Nonproliferative Diabetic Retinopathy |
|
|
| Rapidly Progressive Glomerulonephritis |
|
|
| Generalized Atherosclerosis |
|
|
| Pericardium Disease |
|
|
| Aortic Dissection |
|
|
| Perinephritis |
|
|
| Hepatic Vascular Disease |
|
|
| Non-Severe Covid-19 |
|
|
| Renovascular Hypertension |
|
|
| Autosomal Dominant Polycystic Kidney Disease |
|
|
| Acute Anterolateral Myocardial Infarction |
|
|
| Disorder Of Sexual Development |
|
|
| Renal Tubular Dysgenesis |
|
|
| Extrinsic Cardiomyopathy |
|
|
| Intracranial Hypertension |
|
|
| Pre-Eclampsia |
|
|
| Focal Segmental Glomerulosclerosis |
|
|
| Obstructive Nephropathy |
|
|
| Aortic Valve Insufficiency |
|
|
| Cardiovascular System Disease |
|
|
| Glomerulonephritis |
|
|
| Arthrogryposis, Distal, Type 3 |
|
|
| Nephrotic Syndrome |
|
|
| Bartter Syndrome, Type 3 |
|
|
| Heart Conduction Disease |
|
|
| Chronic Pulmonary Heart Disease |
|
|
| Kidney Disease |
|
|
| Lipoid Congenital Adrenal Hyperplasia |
|
|
| Postural Orthostatic Tachycardia Syndrome |
|
|
| Overnutrition |
|
|
| Uremia |
|
|
| Constrictive Pericarditis |
|
|
| Gastroenteritis |
|
|
| Heart Disease |
|
|
| Hypokalemia |
|
|
| Aortic Aneurysm |
|
|
| Cystic Kidney Disease |
|
|
| Aortic Aneurysm, Familial Thoracic 1 |
|
|
| Chronic Pyelonephritis |
|
|
| Autonomic Neuropathy |
|
|
| Diabetes Mellitus, Ketosis-Prone |
|
|
| Polycystic Kidney Disease 4 |
|
|
| Urinary System Disease |
|
|
| Hypertensive Heart Disease |
|
|
| Kidney Hemangiopericytoma |
|
|
| Hypertension, Essential |
|
|
| Hypertrophic Cardiomyopathy |
|
|
| Malignant Secondary Hypertension |
|
|
| Urogenital Tuberculosis |
|
|
| Aortic Aneurysm, Familial Abdominal, 1 |
|
|
| Hypertension, Diastolic |
|
|
| Ureteral Disease |
|
|
| Hypertensive Encephalopathy |
|
|
| Malignant Renovascular Hypertension |
|
|
| Sleep Apnea |
|
|
| Aortic Disease |
|
|
| Primary Hyperparathyroidism |
|
|
| Steroid Inherited Metabolic Disorder |
|
|
| Central Sleep Apnea |
|
|
| Familial Glucocorticoid Deficiency |
|
|
| Tricuspid Valve Disease |
|
|
| Wilms Tumor 1 |
|
|
| Potter'S Syndrome |
|
|
| Hypersensitivity Vasculitis |
|
|
| Migraine With Or Without Aura 1 |
|
|
| Central Pontine Myelinolysis |
|
|
| Oligohydramnios |
|
|
| Tetralogy Of Fallot |
|
|
| Restrictive Cardiomyopathy |
|
|
| Acute Kidney Tubular Necrosis |
|
|
| Malignant Hypertension |
|
|
| Pheochromocytoma |
|
|
| Deficiency Anemia |
|
|
| Polycystic Kidney Disease |
|
|
| Hypoaldosteronism |
|
|
| Patent Ductus Arteriosus 1 |
|
|
| Endocrine Organ Benign Neoplasm |
|
|
| Cholesterol Embolism |
|
|
| Pulmonary Valve Insufficiency |
|
|
| Ovarian Hyperstimulation Syndrome |
|
|
| Background Diabetic Retinopathy |
|
|
| Coronavirus Infectious Disease |
|
|
| Diabetes Mellitus |
|
|
| Adrenal Adenoma |
|
|
| Patent Foramen Ovale |
|
|
| Renal Tuberculosis |
|
|
| Respiratory Failure |
|
|
| Hyperaldosteronism, Familial, Type I |
|
|
| Left Bundle Branch Hemiblock |
|
|
| Alcoholic Cardiomyopathy |
|
|
| Viral Pneumonia |
|
|
| Hepatoblastoma |
|
|
| Tricuspid Valve Insufficiency |
|
|
| Corticosterone Methyloxidase Type I Deficiency |
|
|
| Renal Tubular Acidosis |
|
|
| Congenital Anomalies Of Kidney And Urinary Tract 2 |
|
|
| Eye Disease |
|
|
| Urinary Tract Obstruction |
|
|
| Renal Artery Atheroma |
|
|
| Autoimmune Disease Of Endocrine System |
|
|
| Orthostatic Proteinuria |
|
|
| Conn'S Syndrome |
|
|
| Mesangial Proliferative Glomerulonephritis |
|
|
| Iga Glomerulonephritis |
|
|
| Pseudohypoaldosteronism |
|
|
| Portal Hypertension |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Premenstrual Tension |
|
|
| Tubulointerstitial Kidney Disease, Autosomal Dominant, 4 |
|
|
| Atrial Heart Septal Defect |
|
|
| Pulmonary Artery Disease |
|
|
| Long Covid |
|
|
| Orthostatic Intolerance |
|
|
| Arteries, Anomalies Of |
|
|
| Hepatorenal Syndrome |
|
|
| Anuria |
|
|
| Intrinsic Cardiomyopathy |
|
|
| Adrenal Cortical Carcinoma |
|
|
| Apnea, Obstructive Sleep |
|
|
| Metabolic Acidosis |
|
|
| Pyeloureteritis Cystica |
|
|
| Benign Essential Hypertension |
|
|
| Brachydactyly |
|
|
| Kidney Hypertrophy |
|
|
| Intermediate Coronary Syndrome |
|
|
| Pulmonary Edema |
|
|
| Newborn Respiratory Distress Syndrome |
|
|
| Microvascular Complications Of Diabetes 3 |
|
|
| Neonatal Anemia |
|
|
| Arteriolosclerosis |
|
|
| Acute Kidney Failure |
|
|
| Covid-19 |
|
|
| Adrenal Gland Disease |
|
|
| Eclampsia |
|
|
| Mitral Valve Disease |
|
|
| Pulmonary Hypertension |
|
|
| Pseudohypoaldosteronism, Type I, Autosomal Recessive |
|
|
| Congestive Heart Failure |
|
|
| Vesicoureteral Reflux |
|
|
| Mineral Metabolism Disease |
|
|
| Chondrocalcinosis |
|
|
| Nephrogenic Diabetes Insipidus |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Premature Menopause |
|
|
| Renal Fibrosis |
|
|
| Stroke, Ischemic |
|
|
| Pseudohypoparathyroidism |
|
|
| Acute Cor Pulmonale |
|
|
| Alport Syndrome |
|
|
| Systemic Lupus Erythematosus |
|
|
| Transient Cerebral Ischemia |
|
|
| Twin-To-Twin Transfusion Syndrome |
|
|
| Prostate Embryonal Rhabdomyosarcoma |
|
|
| Hypothyroidism |
|
|
| Autonomic Nervous System Disease |
|
|
| Pure Autonomic Failure |
|
|
| Cardiac Tamponade |
|
|
| Cakut |
|
|
| Chronic Kidney Disease |
|
|
| Carbohydrate Metabolic Disorder |
|
|
| Carotid Stenosis |
|
|
| Polycythemia |
|
|
| Polyhydramnios |
|
|
| Renal Artery Obstruction |
|
|
| Retinal Microaneurysm |
|
|
| Adult Syndrome |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | REN | MGD | MGI:97898 |
| Bos taurus | REN | VGNC | VGNC:33865 |
| Macaca mulatta | REN | VGNC | VGNC:100055 |
| Rattus norvegicus | REN | RGD | RGD:3554 |
| Canis familiaris | REN | VGNC | VGNC:45474 |
| Felis catus | REN | VGNC | VGNC:69286 |
| Others | REN | NCBI |