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Cat. No.: HY-184944

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HsClpP-ligand-1

HsClpP-ligand-1 is an intermediate derived from HsClpP ligands, and also serves as an HsClpP recruitment module for constructing mitochondria-targeted pan-PDK degraders. HsClpP-ligand-1 acts as the HsClpP ligand of the bifunctional degrader Pan-PDK degrader-1 (HY-184943).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₄H₂₃N₅O₂
분자량:413.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

HsClpP-ligand-1 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

HsClpP

In Vitro

HsClpP-ligand-1 (compound 16) is the HsClpP-targeting moiety of the bifunctional degrader Pan-PDK degrader-1 (compound A1) (HY-184943), and forms a stable ternary complex with recombinant human PDK1 and HsClpP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 413.47
화학식 C₂₄H₂₃N₅O₂
SMILES

OC1=C(C=CC=C1)CN2C3=NCCN3C4=C(C2=O)CN(CC4)CC5=CC=CC(C#N)=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yang Y, et al. HsClpP-Engaging Selective Mitochondrial Pan-PDK Degraders for Cancer Therapy. Journal of medicinal chemistry. 2026 Jul 02. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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