country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-130607

Copy Link Print Information

IDO1-IN-2

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC₅₀s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2346614-58-0
화학식: C₁₅H₁₇FN₆O₄
분자량:364.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

IDO1-IN-2 Chemical Structure

CAS No.: 2346614-58-0

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC₅₀s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity^[1].

IC₅₀ & Target^[1]

IDO1

81 nM (IC₅₀)

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	49 nM Compound: 79	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability by MTT assay	[PMID: 33569941]
HeLa	IC₅₀	49 nM Compound: 16	Inhibition of IDO1 in human HeLa cells stimulated with IFNgamma using L-tryptophan as substrate incubated for 48 hrs by fluorescence based assay Inhibition of IDO1 in human HeLa cells stimulated with IFNgamma using L-tryptophan as substrate incubated for 48 hrs by fluorescence based assay	[PMID: 31749906]
SW480	IC₅₀	>10 μM Compound: 16	Inhibition of TDO in human SW480 cells incubated for 48 hrs using L-tryptophan as substrate by fluorescence based assay Inhibition of TDO in human SW480 cells incubated for 48 hrs using L-tryptophan as substrate by fluorescence based assay	[PMID: 31749906]

In Vitro

IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC₅₀ of 49 nM. IDO1-IN-2 has an IC₅₀ of 249 nM for IDO1 wholr blood^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IDO1-IN-2 (100 mg/kg, twice daily) demonstrates good efficacy synergy when combined with anti-PD-1 mAb in a mouse EMT6 tumor syngeneic model^[1].
IDO1-IN-2 has a t_1/2 of 3.7 hours, a CL/CLu of 15/319 mL/min/kg, and a F of 63% for rats. IDO1-IN-2 has a t_1/2 of 6 hours, a CL/CLu of 6/88 mL/min/kg, and a F of 67% for dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2346614-58-0
분자량 364.33
화학식 C₁₅H₁₇FN₆O₄
SMILES

O/N=C(N[C@H]1CC2=C1C=C(F)C=C2)/C3=NON=C3NCC(NCCO)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang H, et al.Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.ACS Med Chem Lett. 2019 Sep 18;10(11):1530-1536. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

IDO1-IN-2

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

IDO1-IN-2 Related Classifications

HY-130607 Related Classifications