JH-LPH-28
Based on 1 Customer Validation
JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.50%
- CAS No.: 2414592-36-0
- 화학식: C21H21F4N3O3S
- 분자량:471.47
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
JH-LPH-28 displays IC50 values of 0.11 μM against K. pneumoniae LpxH and 0.083 μM against E. coli LpxH, respectively[1].
JH-LPH-28 potently inhibits bacterial growth at 2.8 μg/mL and displayes a MIC value of 1.6 μg/mL against wild-type K. pneumoniae (ATCC 10031)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2414592-36-0
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Appearance Solid
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분자량 471.47
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화학식 C21H21F4N3O3S
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Color White to off-white
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SMILES
CC(N1CCC2=C1C=CC(S(=O)(N3CCN(C4=CC(F)=CC(C(F)(F)F)=C4)CC3)=O)=C2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 12.5 mg/mL (26.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1210 mL | 10.6051 mL | 21.2103 mL | 53.0256 mL |
| 5 mM | 0.4242 mL | 2.1210 mL | 4.2421 mL | 10.6051 mL | |
| 10 mM | 0.2121 mL | 1.0605 mL | 2.1210 mL | 5.3026 mL | |
| 15 mM | 0.1414 mL | 0.7070 mL | 1.4140 mL | 3.5350 mL | |
| 20 mM | 0.1061 mL | 0.5303 mL | 1.0605 mL | 2.6513 mL | |
| 25 mM | 0.0848 mL | 0.4242 mL | 0.8484 mL | 2.1210 mL |
JH-LPH-28 Related Classifications
HY-130837 Related Classifications
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