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Lebrikizumab

(Synonyms: TNX-650; MILR1444A; RG3637)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases.

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  • Purity: 99.90%
  • CAS No.: 953400-68-5
  • 분자량:145.318 kDa
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Lebrikizumab
  • Experimental Validation Results for Lebrikizumab
  • Experimental Validation Results for Lebrikizumab
  • Lebrikizumab Chemical Structure
    Lebrikizumab Chemical Structure
CAS No.: 953400-68-5
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Lebrikizumab (HY-P99025) neutralizes Recombinant Human IL-13 (HY-P70568) induced proliferation in the TF-1 human erythroleukemic cell line. The Neutralization Dose (ND50) for this effect is 0.9529 μg/mL in the presence of 10 ng/mL Recombinant Human IL-13.

  • 1/16

    Loaded Lebrikizumab on AHC2 biosensor, can bind IL-13 Protein, Human (HEK293, His, HY-P70568) with an affinity constant of 7.283E-10 M as determined in BLI assay.

  • Lebrikizumab Chemical Structure
    1/16
  • Lebrikizumab
  • Lebrikizumab (HY-P99025) neutralizes Recombinant Human IL-13 (HY-P70568) induced proliferation in the TF-1 human erythroleukemic cell line. The Neutralization Dose (ND50) for this effect is 0.9529 μg/mL in the presence of 10 ng/mL Recombinant Human IL-13.
  • Loaded Lebrikizumab on AHC2 biosensor, can bind IL-13 Protein, Human (HEK293, His, HY-P70568) with an affinity constant of 7.283E-10 M as determined in BLI assay.